Bacillus paralicheniformis, an acetate-producing probiotic, alleviates ulcerative colitis via protecting the intestinal barrier and regulating the NLRP3 inflammasome

被引:5
作者
Dai, Nini [1 ,2 ,3 ]
Yang, Xinting [1 ,2 ,3 ]
Pan, Peilong [1 ,2 ,3 ]
Zhang, Guanghui [1 ,2 ,3 ]
Sheng, Kangliang [1 ,2 ,3 ]
Wang, Jingmin [1 ,2 ,3 ]
Liang, Xiao [1 ,2 ,3 ]
Wang, Yongzhong [1 ,2 ,3 ]
机构
[1] Anhui Univ, Sch Life Sci, Hefei, Peoples R China
[2] Anhui Univ, Anhui Higher Educ Inst, Key Lab Human Microenvironm & Precis Med, Hefei, Peoples R China
[3] Anhui Prov Joint Construct Discipline Key Lab Nano, Hefei, Peoples R China
基金
中国国家自然科学基金;
关键词
Bacillus paralicheniformis; Genome mining; Acetate; Ulcerative colitis; GUT MICROBIOTA; BOWEL-DISEASE; NONSTARCH POLYSACCHARIDES; NATURAL-RESOURCES; IBD; MICE;
D O I
10.1016/j.micres.2024.127856
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Ulcerative colitis (UC) presents a challenging scenario in digestive health, characterized by recurrent inflammation that is often hard to manage. Bacteria capable of producing short-chain fatty acids (SCFAs) play a pivotal role in mitigating UC symptoms, rendering them promising candidates for probiotic therapy. In this investigation, we assessed the impact of Bacillus paralicheniformis HMPM220325 on dextran sodium sulfate (DSS)-induced UC in mice. Genomic analysis of the strain revealed the presence of protease genes associated with acetate and butyrate synthesis, with acetic acid detected in its fermentation broth. Administration of B. paralicheniformis HMPM220325 to UC mice ameliorated pathological manifestations of the condition and restored intestinal barrier function. Furthermore, B. paralicheniformis HMPM220325 suppressed the activation of the NLRP3 inflammasome signaling pathway and modulated the composition of the intestinal microbiota. These findings shed significant light on the potential of B. paralicheniformis as a probiotic candidate, offering a novel avenue for the prevention and therapeutic intervention of colitis.
引用
收藏
页数:14
相关论文
共 57 条
[1]   Evaluation of different bacterial honey isolates as probiotics and their efficient roles in cholesterol reduction [J].
Abdelsamad, Noura O. ;
Esawy, Mona A. ;
Mahmoud, Zeinab E. ;
El-Shazly, Asmaa, I ;
Elsayed, Tarek R. ;
Gamal, Amira A. .
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY, 2022, 38 (06)
[2]   Safety and efficacy of a feed additive consisting of Bacillus paralicheniformis DSM 5749 and Bacillus subtilis DSM 5750 (BioPlus® 2B) for piglets, calves for fattening and other growing ruminants (Chr. Hansen A/S) [J].
Bampidis, Vasileios ;
Azimonti, Giovanna ;
Bastos, Maria de Lourdes ;
Christensen, Henrik ;
Dusemund, Birgit ;
Durjava, Mojca ;
Kouba, Maryline ;
Lopez-Alonso, Marta ;
Puente, Secundino Lopez ;
Marcon, Francesca ;
Mayo, Baltasar ;
Pechova, Alena ;
Petkova, Mariana ;
Ramos, Fernando ;
Sanz, Yolanda ;
Villa, Roberto Edoardo ;
Woutersen, Ruud ;
Prieto, Miguel ;
Anguita, Montserrat ;
Garcia-Cazorla, Yolanda ;
Innocenti, Matteo L. ;
Lopez-Galvez, Gloria ;
Pettenati, Elisa ;
Revez, Joana ;
Vettori, Maria Vittoria ;
Brozzi, Rosella .
EFSA JOURNAL, 2023, 21 (03)
[3]   Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome [J].
Bauer, Christian ;
Duewell, Peter ;
Mayer, Christine ;
Lehr, Hans Anton ;
Fitzgerald, Katherine A. ;
Dauer, Marc ;
Tschopp, Jurg ;
Endres, Stefan ;
Latz, Eicke ;
Schnurr, Max .
GUT, 2010, 59 (09) :1192-1199
[4]   Treatment of IBD: Where We Are and Where We Are Going [J].
Bernstein, Charles N. .
AMERICAN JOURNAL OF GASTROENTEROLOGY, 2015, 110 (01) :114-126
[5]   Characterization of the starch surface binding site on Bacillus paralicheniformis α-amylase [J].
Bozic, Natasa ;
Rozeboom, Henriette J. ;
Loncar, Nikola ;
Slavic, Marinela Sokarda ;
Janssen, Dick B. ;
Vujcic, Zoran .
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2020, 165 :1529-1539
[6]   Dietary Composition and Effects in Inflammatory Bowel Disease [J].
Castro, Fernando ;
de Souza, Heitor S. P. .
NUTRIENTS, 2019, 11 (06)
[7]   Inflammatory bowel disease and immunonutrition: novel therapeutic approaches through modulation of diet and the gut microbiome [J].
Celiberto, Larissa S. ;
Graef, Franziska A. ;
Healey, Genelle R. ;
Bosman, Else S. ;
Jacobson, Kevan ;
Sly, Laura M. ;
Vallance, Bruce A. .
IMMUNOLOGY, 2018, 155 (01) :36-52
[8]   Probiotics: The scientific evidence in the context of inflammatory bowel disease [J].
Celiberto, Larissa Sbaglia ;
Bedani, Raquel ;
Rossi, Elizeu Antonio ;
Umbelino Cavallini, Daniela Cardoso .
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION, 2017, 57 (09) :1759-1768
[9]   The water-soluble non-starch polysaccharides from natural resources against excessive oxidative stress: A potential health-promoting effect and its mechanisms [J].
Chen, Xianxiang ;
Wang, Yikun ;
Shen, Mingyue ;
Yu, Qiang ;
Chen, Yi ;
Huang, Lixin ;
Xie, Jianhua .
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2021, 171 :320-330
[10]   Orally Administered CLA Ameliorates DSS-Induced Colitis in Mice via Intestinal Barrier Improvement, Oxidative Stress Reduction, and Inflammatory Cytokine and Gut Microbiota Modulation [J].
Chen, Yang ;
Yang, Bo ;
Ross, R. Paul ;
Jin, Yan ;
Stanton, Catherine ;
Zhao, Jianxin ;
Zhang, Hao ;
Chen, Wei .
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2019, 67 (48) :13282-13298