Modular synthesis of 3,3-disubstituted oxindoles from nitrones and acrylic acids

被引：1

作者：

Suzuki, Hirotsugu ^{[1
]}

Sekino, Kaisei ^{[2
]}

Kondo, Sora ^{[2
]}

Minamikawa, Ryo ^{[2
]}

Matsuda, Takanori ^{[2
]}

机构：

[1] Univ Fukui, Tenure Track Program Innovat Res, 3-9-1 Bunkyo, Fukui, Fukui 9108507, Japan

[2] Tokyo Univ Sci, Dept Appl Chem, 1-3 Kagurazaka, Tokyo, Tokyo 1628601, Japan

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2024年 / 22卷 / 31期

关键词：

HIGHLY ENANTIOSELECTIVE SYNTHESIS; PERICYCLIC CASCADE APPROACH; CARBOXYLIC-ACIDS; ALKYNYLATION; ISATINS; 2-OXINDOLES; SPIROOXINDOLES; 3-HYDROXY; C-SP2-H; ALKYNES;

D O I：

10.1039/d4ob00964a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We developed a modular synthesis for 3,3-disubstituted oxindoles, utilising readily accessible nitrones and acrylic acids. This approach facilitates the preparation of a diverse array of oxindoles through the variation of the starting materials. We demonstrated the applicability of this method through a gram-scale reaction and a synthesis of esermethole. A novel modular synthetic method for 3,3-disubstituted oxindole has been developed, utilising easily preparable and stable nitrones and carboxylic acids.

引用

页码：6282 / 6287

页数：6

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