Unveiling the role of long non-coding RNA MALAT1: a comprehensive review on myocardial infarction

被引:1
作者
Eshraghi, Reza [1 ]
Sadati, Sina [1 ]
Bahrami, Ashkan [1 ]
Mirjalili, Seyed Reza [2 ]
Farrokhian, Alireza [3 ]
Mahjoubin-Tehran, Maryam [4 ]
Mirzaei, Hamed [5 ]
机构
[1] Kashan Univ Med Sci, Student Res Comm, Kashan, Iran
[2] Shahid Sadoughi Univ Med Sci, Non Communicable Dis Res Inst, Yazd Cardiovasc Res Ctr, Yazd, Iran
[3] Kashan Univ Med Sci, Sch Med, Dept Cardiol, Kashan, Iran
[4] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran
[5] Kashan Univ Med Sci, Inst Basic Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran
来源
FRONTIERS IN CARDIOVASCULAR MEDICINE | 2024年 / 11卷
关键词
myocardial infarction; long non-coding RNA; metastasis associated lung adenocarcinoma transcript 1; epigenetic; pathology; KRUPPEL-LIKE FACTOR-2; MHC CLASS-I; LNCRNA MALAT1; TGF-BETA; ENDOTHELIAL-CELLS; TRANSCRIPTIONAL REGULATOR; CARDIOVASCULAR-DISEASE; REPERFUSION INJURY; EARLY-DIAGNOSIS; DOWN-REGULATION;
D O I
10.3389/fcvm.2024.1429858
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Myocardial infarction (MI) stands at top global causes of death in developed countries, owing mostly to atherosclerotic plaque growth and endothelial injury-induced reduction in coronary blood flow. While early reperfusion techniques have improved outcomes, long-term treatment continues to be difficult. The function of lncRNAs extends to regulating gene expression in various conditions, both physiological and pathological, such as cardiovascular diseases. The objective of this research is to extensively evaluate the significance of the lncRNA called Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) in the development and management of MI. According to research, MALAT1 is implicated in processes such as autophagy, apoptosis, cell proliferation, and inflammation in the cardiovascular system. This investigation examines recent research examining the effects of MALAT1 on heart function and its potential as a mean of diagnosis and treatment for post- MI complications and ischemic reperfusion injury.
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页数:13
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