Advancing Bacillus licheniformis as a Superior Expression Platform through Promoter Engineering

被引:1
作者
Xiao, Fengxu [1 ,2 ,3 ,4 ]
Zhang, Yupeng [1 ,2 ,3 ,4 ]
Zhang, Lihuan [1 ,2 ,3 ]
Li, Siyu [1 ,2 ,3 ]
Chen, Wei [4 ]
Shi, Guiyang [1 ,2 ,3 ]
Li, Youran [1 ,2 ,3 ]
机构
[1] Jiangnan Univ, Sch Biotechnol, Key Lab Ind Biotechnol, Minist Educ, Wuxi 214122, Peoples R China
[2] Jiangnan Univ, Natl Engn Res Ctr Cereal Fermentat & Food Biomfg, 1800 Lihu Ave, Wuxi 214122, Peoples R China
[3] Jiangnan Univ, Jiangsu Prov Engn Res Ctr Bioact Prod Proc, Wuxi 214122, Peoples R China
[4] Jiangnan Univ, Sch Food Sci & Technol, Wuxi 214122, Peoples R China
关键词
Bacillus licheniformis; promoter; promoter engineering; HIGH-LEVEL PRODUCTION; MOLECULAR CHARACTERIZATION; BIOSYNTHESIS OPERON; CONSTRUCTION; ENHANCEMENT; ACETOIN; PEPTIDE; SYSTEM;
D O I
10.3390/microorganisms12081693
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Bacillus licheniformis is recognised as an exceptional expression platform in biomanufacturing due to its ability to produce high-value products. Consequently, metabolic engineering of B. licheniformis is increasingly pursued to enhance its utility as a biomanufacturing vehicle. Effective B. licheniformis cell factories require promoters that enable regulated expression of target genes. This review discusses recent advancements in the characterisation, synthesis, and engineering of B. licheniformis promoters. We highlight the application of constitutive promoters, quorum sensing promoters, and inducible promoters in protein and chemical synthesis. Additionally, we summarise efforts to expand the promoter toolbox through hybrid promoter engineering, transcription factor-based inducible promoter engineering, and ribosome binding site (RBS) engineering.
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页数:14
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