Terahertz Time-Domain Spectroscopy Imaging of Pancreatic Ductal Adenocarcinoma Tissues

被引：0

作者：

Chakraborty, Debamitra ^{[1
,2
]}

Mills, Bradley N. ^{[3
]}

Cheng, Jing ^{[1
,2
]}

Komissarov, Ivan ^{[2
,4
]}

Gerber, Scott A. ^{[3
]}

Sobolewski, Roman ^{[1
,2
,4
]}

机构：

[1] Univ Rochester, Mat Sci Grad Program, Rochester, NY 14627 USA

[2] Univ Rochester, Lab Laser Energet, Rochester, NY 14627 USA

[3] Univ Rochester, Dept Surg, Rochester, NY USA

[4] Univ Rochester, Dept Elect & Comp Engn, Rochester, NY 14627 USA

来源：

TISSUE OPTICS AND PHOTONICS III | 2024年 / 13010卷

基金：

美国能源部;

关键词：

Terahertz time-domain spectroscopy; pancreatic cancer; two-dimensional terahertz imaging; medical imaging; image processing; pancreatic ductal adenocarcinoma; femtosecond laser technique;

D O I：

10.1117/12.3023034

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Pancreatic ductal adenocarcinoma (PDAC) ranks among the malignancies with the highest fatality and morbidity rates. This is predominantly attributable to an absence of understanding the intricate and diverse microenvironment of the tumor. We use terahertz time-domain spectroscopy (THz-TDS) imaging in transmission geometry to probe ex-vivo the heterogenous microenvironment of the genetically modified murine PDAC tissue that closely resembles the PDAC heterogeneity in human malignancy. We introduced a maximum a-posteriori probability estimation algorithm to objectively the tumor's heterogenous microenvironment using the average values of refractive index and absorption coefficient within the useable terahertz bandwidth as imaging markers. Direct comparison of stained histopathologic images and the refractive index and the absorption coefficient high-resolution, two-dimensional maps of the same PDAC samples confirms the high potential of the THz-TDS method for tumor tissue characterization.

引用

页数：5