Mechanisms of action and applications of Polygonatum sibiricum polysaccharide at the intestinal mucosa barrier: a review

被引：0
|
作者：
Ren, Yu [1 ,2 ]
Sun, Yi [1 ]
Liao, Yu-Ying [3 ]
Wang, Si [1 ,4 ]
Liu, Qian [1 ]
Duan, Chun-Yan [3 ]
Sun, Lan [1 ]
Li, Xiao-Ya [1 ]
Yuan, Jia-Li [1 ]
机构：
[1] Yunnan Univ Chinese Med, Sch Basic Med Sci, Yunnan Prov Key Lab Integrated Tradit Chinese & We, Kunming, Yunnan, Peoples R China
[2] China Acad Chinese Med Sci, Xiyuan Hosp, Beijing, Peoples R China
[3] Yunnan Univ Chinese Med, Coll Tradit Chinese Med, Kunming, Yunnan, Peoples R China
[4] Yunnan Univ Chinese Med, Clin Med Coll 1, Kunming, Yunnan, Peoples R China
来源：
FRONTIERS IN PHARMACOLOGY | 2024年 / 15卷
关键词：
Polygonatum sibiricum; Polygonatum sibiricum polysaccharide; homology of medicine and food; intestinal mucosal barrier; short-chain fatty acids; DYSFUNCTION; MICROBIOTA; STRESS; FRUCTOOLIGOSACCHARIDES; BALANCE; HEALTH; CELLS; MICE;
D O I：
10.3389/fphar.2024.1421607
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
As a medicinal and edible homologous Chinese herb, Polygonatum sibiricum has been used as a primary ingredient in various functional and medicinal products. Damage to the intestinal mucosal barrier can lead to or worsen conditions such as type 2 diabetes and Alzheimer's disease. Traditional Chinese medicine and its bioactive components can help prevent and manage these conditions by restoring the integrity of the intestinal mucosal barrier. This review delves into the mode of action of P. sibiricum polysaccharide in disease prevention and management through the restoration of the intestinal barrier. Polysaccharide from P. sibiricum effectively treats conditions by repairing the intestinal mucosal barrier, offering insights for treating complex diseases and supporting the application of P. sibiricum in clinical settings.
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页数：13
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