Sulfation of Allobetulin with Sulfamic Acid in N, N-dimethylformamide and 1,4-dioxane

被引：0
|
作者：
Levdansky, Vladimir A. [1 ]
Ivanenko, Timur Yu. [1 ]
Levdansky, Alexander V. [1 ]
机构：
[1] RAS, Inst Chem & Chem Technol, SB, FRC,KSC, Krasnoyarsk, Russia
来源：
JOURNAL OF SIBERIAN FEDERAL UNIVERSITY-CHEMISTRY | 2024年 / 17卷 / 03期
关键词：
allobetulin; sulfation; sulfamic acid; urea; 1,4-dioxane; N; N-dimethylformamide; 3-sulfate; CYTOTOXICITY; BETULIN;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Sulfuric acid esters of betulin and its numerous derivatives are of interest to the chemical and pharmaceutical industry as complement inhibitors. The development of new efficient methods for the synthesis of sulfuric acid esters of betulin and its derivatives is an actual task. The sulfation of allobetulin with sulfamic acid in the presence of urea in a medium of 1,4-dioxane and N, N-dimethylformamide was studied for the first time. It was found that the reaction proceeds in a homogeneous medium at a temperature of 70-75 degrees C in 3-4 hours with the formation of allobetulin 3-sulfate. The structure of allobetulin 3-sulfate was confirmed by FTIR and NMR spectroscopy, and its composition was confirmed by elemental analysis.
引用
收藏
页码：448 / 456
页数：9
相关论文
共 50 条
  • [41] Sulfation of betulin with chlorosulfonic acid in dimethylformamide and dioxane
    V. A. Levdansky
    A. V. Levdansky
    B. N. Kuznetsov
    Russian Journal of Bioorganic Chemistry, 2014, 40 : 748 - 751
  • [42] catena-Poly[[[diaquabis(N,N-dimethylformamide)cobalt(II)]-μ-1,4-benzenedicarboxylato-κ2O:O′] N,N-dimethylformamide solvate monohydrate]
    Jia, Chun-Xiao
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2007, 63 : M615 - M616
  • [43] THERMODYNAMIC PROPERTIES OF BINARY-MIXTURES CONTAINING SULFUR AMIDE .2. EXCESS MOLAR VOLUMES OF 1,4-DIOXANE + N,N-DIMETHYLMETHANESULFINAMIDE AND 1,4-DIOXANE + N-METHYLMETHANESULFINAMIDE
    RUOSTESUO, P
    MATTILA, T
    JOURNAL OF CHEMICAL AND ENGINEERING DATA, 1987, 32 (02): : 241 - 243
  • [44] N,N-DIMETHYLFORMAMIDE (DMF)
    DOI, S
    JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 1982, 40 (05) : 446 - 446
  • [45] EXCESS VOLUMES FOR TETRACHLOROMETHANE + N,N-DIMETHYLFORMAMIDE, + N,N-DIMETHYLACETAMIDE, + P-DIOXANE, AND + DIMETHYLSULFOXIDE
    GRIGG, RB
    GOATES, JR
    OTT, JB
    JOURNAL OF CHEMICAL THERMODYNAMICS, 1979, 11 (07): : 703 - 708
  • [46] Acoustical studies of schiff bases in 1,4-dioxane and dimethylformamide at 318.15 K
    Baluja, Sh.
    Shah, A.
    RUSSIAN JOURNAL OF PHYSICAL CHEMISTRY, 2006, 80 (07): : 1056 - 1060
  • [47] Acoustical studies of schiff bases in 1,4-dioxane and dimethylformamide at 318.15 K
    Sh. Baluja
    A. Shah
    Russian Journal of Physical Chemistry, 2006, 80 : 1056 - 1060
  • [48] Acoustical studies of Schiff bases in 1,4-dioxane and dimethylformamide at 308.15 K
    Baluja, S
    Inamdar, P
    Soni, M
    ACTA PHYSICO-CHIMICA SINICA, 2004, 20 (09) : 1104 - 1107
  • [49] 1,5-Diphenylcarbonohydrazide N,N-dimethylformamide
    Zhang, Ai-yun
    Ma, Si-yao
    Bu, Dong
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2010, 66 : O2734 - U1865
  • [50] Thermodynamic investigation of the orthophosphoric acid -: N,N-dimethylformamide system
    Safonova, LP
    Fadeeva, YA
    Shmukler, LE
    Kinchin, AN
    JOURNAL OF MOLECULAR LIQUIDS, 2005, 121 (01) : 53 - 57
12345