Sulfation of Allobetulin with Sulfamic Acid in N, N-dimethylformamide and 1,4-dioxane

被引：0
作者：
Levdansky, Vladimir A. [1 ]
Ivanenko, Timur Yu. [1 ]
Levdansky, Alexander V. [1 ]
机构：
[1] RAS, Inst Chem & Chem Technol, SB, FRC,KSC, Krasnoyarsk, Russia
来源：
JOURNAL OF SIBERIAN FEDERAL UNIVERSITY-CHEMISTRY | 2024年 / 17卷 / 03期
关键词：
allobetulin; sulfation; sulfamic acid; urea; 1,4-dioxane; N; N-dimethylformamide; 3-sulfate; CYTOTOXICITY; BETULIN;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Sulfuric acid esters of betulin and its numerous derivatives are of interest to the chemical and pharmaceutical industry as complement inhibitors. The development of new efficient methods for the synthesis of sulfuric acid esters of betulin and its derivatives is an actual task. The sulfation of allobetulin with sulfamic acid in the presence of urea in a medium of 1,4-dioxane and N, N-dimethylformamide was studied for the first time. It was found that the reaction proceeds in a homogeneous medium at a temperature of 70-75 degrees C in 3-4 hours with the formation of allobetulin 3-sulfate. The structure of allobetulin 3-sulfate was confirmed by FTIR and NMR spectroscopy, and its composition was confirmed by elemental analysis.
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页码：448 / 456
页数：9
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