GL-V9 induce apoptosis of CML cells via MAPK signaling pathway

被引：0
|
作者：
Jiang, Fengyu [1 ]
Xue, Yangyang [1 ]
Zhang, Qin [1 ]
Ma, Tonghui [1 ]
Li, Yongming [1 ]
Yu, Xiaoxuan [1 ,2 ]
机构：
[1] Nanjing Univ Chinese Med, Jiangsu Collaborat Innovat Ctr Chinese Med Resourc, Sch Med, Nanjing 210023, Peoples R China
[2] Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Peoples R China
来源：
HELIYON | 2024年 / 10卷 / 14期
基金：
中国国家自然科学基金;
关键词：
GL-V9; CML; Apoptosis; MAPK;
D O I：
10.1016/j.heliyon.2024.e34030
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
GL-V9, a derivative of wogonin, has shown potent antitumor effects in various cancers, yet its impact on chronic myeloid leukemia (CML) remains unexplored. In this study, we found that GLV9 significantly decreased the viability of CML cells. Annexin V/PI staining demonstrated that GL-V9 induced apoptosis in a concentration-dependent manner. The JC-1 assay indicated a significant reduction in mitochondrial membrane potential (Delta Psi m) in cells treated with GL-V9. Additionally, GL-V9 altered reactive oxygen species (ROS) levels in CML cells. Through transcriptomic sequencing and Western blot analysis, we further revealed that GL-V9 activated the MAPK pathway. These results suggest that GL-V9 is a promising therapeutic candidate for CML.
引用
收藏
页数：10
相关论文
共 50 条
  • [21] Statins induce apoptosis in osteosarcoma cells by activation of Ampk and p38-MAPK via suppression of mevalonate pathway
    Kamel, Walied Abd-Elghani
    Sugihara, Eiji
    Yamaguchi, Sayaka Iwai
    Nobusue, Hiroyuki
    Maki, Kenta
    Muto, Akihiro
    Saya, Hideyuki
    Shimizu, Takatsune
    CANCER RESEARCH, 2016, 76
  • [22] Polystyrene microplastics induce apoptosis and necroptosis in swine testis cells via ROS/MAPK/HIF1α pathway
    Wang, Xu
    Zhang, Xinyu
    Sun, Kexin
    Wang, Shengchen
    Gong, Duqiang
    ENVIRONMENTAL TOXICOLOGY, 2022, 37 (10) : 2483 - 2492
  • [23] GL-V9 inhibits the activation of AR-AKT-HK2 signaling networks and induces prostate cancer cell apoptosis through mitochondria-mediated mechanism
    Wang, Rui
    Min, Qi
    Guo, Yongjian
    Zhou, Yuxin
    Zhang, Xin
    Wang, Dechao
    Gao, Yuan
    Wei, Libin
    ISCIENCE, 2024, 27 (03)
  • [24] Mechanistic study of absorption and first-pass metabolism of GL-V9, a derivative of wogonin
    Xing, Han
    Ren, Chang
    Kong, Ying
    Ning, Chen
    Kong, Dexuan
    Zhang, Yongjie
    Zhao, Di
    Li, Ning
    Wang, Zeyu
    Chen, Xijing
    Lu, Yang
    BIOPHARMACEUTICS & DRUG DISPOSITION, 2019, 40 (3-4) : 151 - 161
  • [25] Bavachin induces apoptosis in colorectal cancer cells through Gadd45a via the MAPK signaling pathway
    WANG Mengru
    TIAN Baopeng
    SHEN Jie
    XU Shilin
    LIU Cong
    GUAN Ling
    GUO Min
    DOU Jie
    Chinese Journal of Natural Medicines, 2023, 21 (01) : 36 - 46
  • [26] Bavachin induces apoptosis in colorectal cancer cells through Gadd45a via the MAPK signaling pathway
    Wang, Mengru
    Tian, Baopeng
    Shen, Jie
    Xu, Shilin
    Liu, Cong
    Guan, Ling
    Guo, Min
    Dou, Jie
    CHINESE JOURNAL OF NATURAL MEDICINES, 2023, 21 (01) : 36 - 46
  • [27] Cadmium induced BEAS-2B cells apoptosis and mitochondria damage via MAPK signaling pathway
    Cao, Xiangyu
    Fu, Mingyang
    Bi, Ruochen
    Zheng, Xiaomei
    Fu, Baorong
    Tian, Siqi
    Liu, Chengying
    Li, Qijiu
    Liu, Jianli
    CHEMOSPHERE, 2021, 263
  • [28] Silymarin inhibits proliferation of human breast cancer cells via regulation of the MAPK signaling pathway and induction of apoptosis
    Kim, Sung-Hyun
    Choo, Gang-Sik
    Yoo, Eun-Seon
    Woo, Joong-Seok
    Lee, Jae-Han
    Han, So-Hee
    Jung, Soo-Hyun
    Kim, Hyeong-Jin
    Jung, Ji-Youn
    ONCOLOGY LETTERS, 2021, 21 (06)
  • [29] Zeaxanthin Induces Apoptosis via ROS-Regulated MAPK and AKT Signaling Pathway in Gastric Cancer Cells
    Sheng, Ya-Nan
    Luo, Ying-Hua
    Liu, Shao-Bin
    Xu, Wan-Ting
    Zhang, Yu
    Zhang, Tong
    Xue, Hui
    Zuo, Wen-Bo
    Li, Yan-Nan
    Wang, Chang-Yuan
    Jin, Cheng-Hao
    ONCOTARGETS AND THERAPY, 2020, 13 : 10995 - 11006
  • [30] Isoimperatorin Induces Apoptosis of Nasopharyngeal Carcinoma Cells via the MAPK/ERK1/2 Signaling Pathway
    Liu, Jie
    He, Lan
    Hu, Jing
    Li, Kairui
    Zhou, Fangliang
    Hu, Mei
    Luo, Jingjing
    Song, Lan
    He, Yingchun
    EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2020, 2020
12345