Relationship between Pyochelin and Pseudomonas Quinolone Signal in Pseudomonas aeruginosa: A Direction for Future Research

被引:0
|
作者
Ma, Xin [1 ]
Zeng, Jing [1 ]
Xiao, Wei [1 ]
Li, Wenwen [1 ]
Cheng, Juanli [1 ]
Lin, Jinshui [1 ]
机构
[1] Yanan Univ, Coll Life Sci, Shaanxi Key Lab Chinese Jujube, Yanan 716000, Peoples R China
基金
中国国家自然科学基金;
关键词
Pseudomonas aeruginosa; quorum sensing; iron uptake; pyochelin; PQS; transporter; PEPTIDE SIDEROPHORE PYOCHELIN; IRON UPTAKE PATHWAY; SALICYLATE BIOSYNTHESIS; ISOCHORISMATE SYNTHASE; ANTHRANILATE SYNTHASES; MEMBRANE TRANSPORTERS; CRYSTAL-STRUCTURE; PQS; ENZYME; TRYPTOPHAN;
D O I
10.3390/ijms25168611
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Pseudomonas aeruginosa is an opportunistic pathogen that requires iron to survive in the host; however, the host immune system limits the availability of iron. Pyochelin (PCH) is a major siderophore produced by P. aeruginosa during infection, which can help P. aeruginosa survive in an iron-restricted environment and cause infection. The infection activity of P. aeruginosa is regulated by the Pseudomonas quinolone signal (PQS) quorum-sensing system. The system uses 2-heptyl-3-hydroxy-4-quinolone (PQS) or its precursor, 2-heptyl-4-quinolone (HHQ), as the signal molecule. PQS can control specific life processes such as mediating quorum sensing, cytotoxicity, and iron acquisition. This review summarizes the biosynthesis of PCH and PQS, the shared transport system of PCH and PQS, and the regulatory relationship between PCH and PQS. The correlation between the PQS and PCH is emphasized to provide a new direction for future research.
引用
收藏
页数:10
相关论文
共 50 条
  • [41] Research of the heteroresistance of Pseudomonas aeruginosa to imipenem
    Mei, Shencong
    Gao, Yulu
    Zhu, Changtai
    Dong, Chunlei
    Chen, Yawen
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2015, 8 (04): : 6129 - 6132
  • [42] The healing effect of Pseudomonas Quinolone Signal (PQS) with co-infection of Staphylococcus aureus and Pseudomonas aeruginosa: A preclinical animal co-infection model
    Dehbashi, Sanaz
    Tahmasebi, Hamed
    Alikhani, Mohammad Yousef
    Vidal, Jorge E.
    Seifalian, Alexander
    Arabestani, Mohammad Reza
    JOURNAL OF INFECTION AND PUBLIC HEALTH, 2024, 17 (02) : 329 - 338
  • [43] Relationship between biofilm formation of Pseudomonas aeruginosa and susceptibility to rifaximin and ofloxacin
    Ghafil, Jenan Atiyah
    Al-Sudani, Susan Fawzi Khadhem
    Ibrahim, Bashar Mohammed Salih
    Alshahrani, Ali M.
    Zgair, Ayaid Khadem
    PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2024, 37 (06) : 1609 - 1614
  • [44] Novel intermicrobial molecular interaction: Pseudomonas aeruginosa Quinolone Signal (PQS) modulates Aspergillus fumigatus response to iron
    Nazik, Hasan
    Sass, Gabriele
    Ansari, Shajia R.
    Ertekin, Reyhan
    Haas, Hubertus
    Deziel, Eric
    Stevens, David A.
    MICROBIOLOGY-SGM, 2020, 166 (01): : 44 - 55
  • [45] RELATIONSHIP BETWEEN ANTIMICROBIAL AND ANTISEPTIC RESISTANCE IN PSEUDOMONAS-AERUGINOSA STRAINS
    MARTINS, FM
    DASILVA, MG
    FILHO, PPG
    REVISTA DE MICROBIOLOGIA, 1991, 22 (01): : 34 - 38
  • [46] Susceptibility of Pseudomonas aeruginosa to catechol-substituted cephalosporin is unrelated to the pyochelin–Fe transporter FptA
    Françoise Hoegy
    Michael N. Gwynn
    Isabelle J. Schalk
    Amino Acids, 2010, 38 : 1627 - 1629
  • [47] Regulation of Alkyl-dihydrothiazole-carboxylates (ATCs) by Iron and the Pyochelin Gene Cluster in Pseudomonas aeruginosa
    Vinayavekhin, Nawaporn
    Saghatelian, Alan
    ACS CHEMICAL BIOLOGY, 2009, 4 (08) : 617 - 623
  • [48] Functional analysis of pyochelin-/enantiopyochelin-related genes from a pathogenicity island of Pseudomonas aeruginosa strain PA14
    Maspoli, Alessandro
    Wenner, Nicolas
    Mislin, Gaetan L. A.
    Reimmann, Cornelia
    BIOMETALS, 2014, 27 (03) : 559 - 573
  • [49] Structure-Activity Analysis of the Pseudomonas Quinolone Signal Molecule
    Hodgkinson, James
    Bowden, Steven D.
    Galloway, Warren R. J. D.
    Spring, David R.
    Welch, Martin
    JOURNAL OF BACTERIOLOGY, 2010, 192 (14) : 3833 - 3837
  • [50] The Pseudomonas quinolone signal (PQS) stimulates chemotaxis of polymorphonuclear neutrophils
    Haensch, Gertrud M.
    Prior, Birgit
    Brenner-Weiss, Gerald
    Obst, Ursula
    Overhage, Joerg
    JOURNAL OF APPLIED BIOMATERIALS & FUNCTIONAL MATERIALS, 2014, 12 (01) : 21 - 26