Relationship between Pyochelin and Pseudomonas Quinolone Signal in Pseudomonas aeruginosa: A Direction for Future Research

被引:0
|
作者
Ma, Xin [1 ]
Zeng, Jing [1 ]
Xiao, Wei [1 ]
Li, Wenwen [1 ]
Cheng, Juanli [1 ]
Lin, Jinshui [1 ]
机构
[1] Yanan Univ, Coll Life Sci, Shaanxi Key Lab Chinese Jujube, Yanan 716000, Peoples R China
基金
中国国家自然科学基金;
关键词
Pseudomonas aeruginosa; quorum sensing; iron uptake; pyochelin; PQS; transporter; PEPTIDE SIDEROPHORE PYOCHELIN; IRON UPTAKE PATHWAY; SALICYLATE BIOSYNTHESIS; ISOCHORISMATE SYNTHASE; ANTHRANILATE SYNTHASES; MEMBRANE TRANSPORTERS; CRYSTAL-STRUCTURE; PQS; ENZYME; TRYPTOPHAN;
D O I
10.3390/ijms25168611
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Pseudomonas aeruginosa is an opportunistic pathogen that requires iron to survive in the host; however, the host immune system limits the availability of iron. Pyochelin (PCH) is a major siderophore produced by P. aeruginosa during infection, which can help P. aeruginosa survive in an iron-restricted environment and cause infection. The infection activity of P. aeruginosa is regulated by the Pseudomonas quinolone signal (PQS) quorum-sensing system. The system uses 2-heptyl-3-hydroxy-4-quinolone (PQS) or its precursor, 2-heptyl-4-quinolone (HHQ), as the signal molecule. PQS can control specific life processes such as mediating quorum sensing, cytotoxicity, and iron acquisition. This review summarizes the biosynthesis of PCH and PQS, the shared transport system of PCH and PQS, and the regulatory relationship between PCH and PQS. The correlation between the PQS and PCH is emphasized to provide a new direction for future research.
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页数:10
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