Research trends and hotspots of ferroptosis in neurodegenerative diseases from 2013 to 2023: A bibliometrics study

被引:4
|
作者
Liu, Ning [1 ]
Yu, Wuhan [2 ,4 ]
Sun, Mengjiao [5 ]
Zhou, Dan [6 ]
Sun, Jing [1 ]
Jiang, Taotao [1 ]
Zhang, Wenjing [3 ]
Wang, Manxia [1 ]
机构
[1] Lanzhou Univ Second Hosp, Dept Neurol, Lanzhou 730030, Peoples R China
[2] Lanzhou Univ Second Hosp, Dept Gen Surg, Lanzhou 730030, Peoples R China
[3] Qinghai Prov Peoples Hosp, Dept Neurol, Qinghai 810000, Peoples R China
[4] Guangdong Med Univ, Dongguan Affiliated Hosp 1, Dept Anus & Intestine Surg, Dongguan 523000, Peoples R China
[5] Capital Med Univ, Beijing 100000, Peoples R China
[6] Xian Ninth Hosp, Dept Neurol, Xian 710000, Peoples R China
关键词
Bibliometric analysis; Ferroptosis; Neurodegenerative diseases; Brain-aging; Web of science; GLUTATHIONE-PEROXIDASE; 4; CELL-DEATH; COGNITIVE IMPAIRMENT; IRON; METABOLISM; ABLATION; BIOLOGY; FORM;
D O I
10.1016/j.heliyon.2024.e29418
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Background: With the aging population, the incidence of neurodegenerative diseases increases yearly, seriously impacting human health. Various journals have published studies on the pathogenesis of ferroptosis in neurodegenerative diseases. However, bibliometric analysis in this field is still lacking. The study aims to visually analyze global research trends in this field over the past decade. Methods: The articles and reviews regarding ferroptosis in neurodegenerative diseases were retrieved from the Web of Science on September 1, 2023. Citespace [version 6.2. R4 (64-bit)] and VOSviewer (version 1.6.18) were used to conduct the bibliometric and knowledge-map analysis. Results: In total, 370 studies were included in the paper and ranked by their citation frequency. Many articles on ferroptosis in neurodegenerative diseases have been published in the past decade. The country, institution, author, and journal with the highest publications were China, Guangzhou Medical University, Maher, Pamela, and Free Radical Biology And Medicine, respectively. The analysis of keyword co-occurrence indicated that research frontiers were molecular mechanisms of ferroptosis in neurodegenerative diseases, especially a few key pathways that triggered ferroptosis in these diseases, including lipid peroxidation signaling, iron metabolism, and GSH/GPX4 signaling. In addition, ferroptosis inhibitors such as liproxstatins and ferrostatins had protective effects in animal models of neurodegenerative diseases. Therefore, future attention should also be focused on therapeutic drugs that target ferroptosis. Conclusion: This study comprehensively analyzed the publications on ferroptosis in neurodegenerative diseases from a bibliometric perspective. Research on this topic is currently expanding at a rapid pace, and the China holds a leading position in this field by its scientific achievements and productivity. Moreover, the research frontiers were molecular mechanisms of ferroptosis in neurodegenerative diseases and developing targeted therapeutic drugs. In summary, our results showed an all-sided overview of the knowledge atlas and a valuable reference for the future research in this field.
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页数:17
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