J-shaped relationship of serum neurofilament light chain with urinary albumin excretion in US adults: NHANES 2013-2014

被引：1
|
作者：
Liu, Yanting [1 ]
Yang, Qian [1 ]
Zhang, Meiyun [2 ]
Lin, Jingna [3 ]
机构：
[1] Tianjin Med Univ, Tianjin Union Med Ctr, Tianjin, Peoples R China
[2] Tianjin Union Med Ctr, Dept Neurol, Tianjin, Peoples R China
[3] Tianjin Union Med Ctr, Dept Endocrinol, Tianjin, Peoples R China
来源：
RENAL FAILURE | 2024年 / 46卷 / 02期
关键词：
Serum neurofilament light chain; albumin-to-creatinine ratio; J-shaped curve; NHANES; GLOMERULAR-FILTRATION-RATE; KIDNEY-DISEASE; RENAL-FUNCTION; ASSOCIATION; BIOMARKER; MORTALITY; BLOOD;
D O I：
10.1080/0886022X.2024.2391955
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
IntroductionThis study focuses on investigating the relationship between serum neurofilament light chain (sNfL) and urinary albumin-to-creatinine ratio (uACR) among American adults aged 25-75.MethodsAn analysis was conducted on information gathered from 1741 individuals aged between 25 and 75 who participated in the National Health and Nutrition Examination Survey (NHANES) during the years 2013-2014. Generalized linear models were utilized, and restricted cubic spline (RCS) analysis was conducted to assess a non-linear relationship.ResultsUpon adjusting for multiple variables, a non-linear inverse J-shaped relationship was observed between sNfL and uACR. Compared with individuals in quartile 1 (Q1) of sNfL (2.8-8.3), those with quartile 4 (Q4) (>= 19.1) had an adjusted beta for uACR of 51.57.ConclusionsThe study found a J-shaped curve linking sNfL and uACR in American adults, with a turning point around log(sNfL) 2.928 pg/mL.
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页数：8
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