Association between lymph node ratio and survival outcomes in patients with oral squamous cell carcinoma

被引：1
作者：
Haraguchi, Kazuya [1 ]
Habu, Manabu [1 ]
Takahashi, Osamu [1 ]
Tominaga, Kazuhiro [2 ]
Yoshioka, Izumi [1 ,3 ]
Sasaguri, Masaaki
机构：
[1] Kyushu Dent Univ, Div Oral & Maxillofacial Surg, Dept Sci Phys Funct, Kitakyushu, Fukuoka, Japan
[2] Tobata Kyoritsu Hosp, Dept Oral & Maxillofacial Surg, Kitakyushu, Fukuoka, Japan
[3] Kyushu Dent Univ, Div Oral Med, Dept Sci Phys Funct, Kitakyushu, Fukuoka, Japan
来源：
JOURNAL OF STOMATOLOGY ORAL AND MAXILLOFACIAL SURGERY | 2024年 / 125卷 / 03期
基金：
日本学术振兴会;
关键词：
Oral squamous cell carcinoma; Lymph node ratio; Survival outcomes; Cervical lymph node metastasis; Neck dissection; EXTRACAPSULAR SPREAD; PROGNOSTIC PREDICTOR; DENSITY; CANCER; METASTASES; TRACT; HEAD;
D O I：
10.1016/j.jormas.2024.101816
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
Background: Recent reports have shown that the Lymph node ratio (LNR) is useful for predicting the prognosis in some cancers, however there are few reports on the usefulness of LNR in predicting the prognosis of oral squamous cell carcinoma (OSCC). The predictive value of LNR for prognosis of OSCC was investigated. Materials and methods: The study included 152 patients with OSCC and histologically confirmed cervical lymph node metastasis who underwent neck dissection. We analyzed the relationship between LNR and overall survival (OS) and recurrence-free survival (RFS) retrospectively in these cases, with the relationship between prognosis and clinicopathological findings also examined. Results: Using a receiver operating characteristics curve, the LNR cutoff value was set at 0.095, categorizing 64 and 88 cases into high LNR (>= 0.095) and low LNR (< 0.095) groups, respectively. Regarding OS and RFS, the prognosis was significantly worse in the high LNR group compared with the low LNR group. In multivariate analysis, sex, postoperative nodal stage, and LNR merged as independent prognostic factors. Conclusion: This study's findings suggest that LNR may represent a prognostic indicator in OSCC with cervical lymph node metastasis. (c) 2024 Elsevier Masson SAS. All rights reserved.
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页数：7
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