A colorimetric pocket sensor for rapid detection of chemical injuries caused by sulfur mustard in the war veterans using plasma composition analysis

A pocket sensor was provided by immobilizing twelve color mixtures containing organic dyes and copper-silver bimetallic nanoparticles coated with dopamine (Dopamine/Ag@Cu BMNPs) on a paper substrate. Due to the catalytic properties of the BMNPs, the index metabolites of the plasma were converted into aldehyde or acid compounds that interacted with the organic dyes. The assay was presented to monitor the changes in the plasma sample's metabolites of 123 injured veteran and 40 healthy people. It is possible to observe the response of sensor with the naked eye within 3 min. To perform this discrimination, the proposed sensor was found to be 87% accurate. The quantitative responses of the sensor were indicated a strong correlation with the severity of the injury. The low cost of the fabrication process, availability, and non-invasiveness of the prepared assay make it an acceptable diagnostic method in hospitals and medical centers.