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- [1] Cytotoxic quinazoline alkaloids from the seeds of Peganum harmalaBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 28 (02) : 103 - 106Li, Sheng-Ge论文数: 0 引用数: 0 h-index: 0机构: Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R China Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R ChinaWang, Kai-Bo论文数: 0 引用数: 0 h-index: 0机构: Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R China Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R ChinaGong, Chi论文数: 0 引用数: 0 h-index: 0机构: Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R China Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R ChinaBao, Yu论文数: 0 引用数: 0 h-index: 0机构: Shenyang Pharmaceut Univ, Sch Life Sci & Biopharmaceut, Shenyang 110016, Liaoning, Peoples R China Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R ChinaQin, Ning-Bo论文数: 0 引用数: 0 h-index: 0机构: Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R China Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R ChinaLi, Da-Hong论文数: 0 引用数: 0 h-index: 0机构: Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R China Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R ChinaLi, Zhan-Lin论文数: 0 引用数: 0 h-index: 0机构: Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R China Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R ChinaBai, Jiao论文数: 0 引用数: 0 h-index: 0机构: Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R China Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R ChinaHua, Hui-Ming论文数: 0 引用数: 0 h-index: 0机构: Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R China Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R China
- [2] New β-carboline alkaloids from the seeds of Peganum harmalaPHYTOCHEMISTRY LETTERS, 2023, 53 : 166 - 169Xu, Ying论文数: 0 引用数: 0 h-index: 0机构: Univ Jinan, Sch Biol Sci & Technol, Jinan 250012, Peoples R China Univ Jinan, Sch Biol Sci & Technol, Jinan 250012, Peoples R ChinaZhao, Xue论文数: 0 引用数: 0 h-index: 0机构: Univ Jinan, Sch Biol Sci & Technol, Jinan 250012, Peoples R China Univ Jinan, Sch Biol Sci & Technol, Jinan 250012, Peoples R ChinaZhang, Di论文数: 0 引用数: 0 h-index: 0机构: Univ Jinan, Sch Biol Sci & Technol, Jinan 250012, Peoples R China Liaocheng Peoples Hosp, Dept Proc Biomed Lab, Liaocheng 252000, Peoples R China Univ Jinan, Sch Biol Sci & Technol, Jinan 250012, Peoples R ChinaYang, Zi-Yi论文数: 0 引用数: 0 h-index: 0机构: Univ Jinan, Sch Biol Sci & Technol, Jinan 250012, Peoples R China Univ Jinan, Sch Biol Sci & Technol, Jinan 250012, Peoples R ChinaXu, Cong-Ying论文数: 0 引用数: 0 h-index: 0机构: Univ Jinan, Sch Biol Sci & Technol, Jinan 250012, Peoples R China Univ Jinan, Sch Biol Sci & Technol, Jinan 250012, Peoples R ChinaLiu, Jie论文数: 0 引用数: 0 h-index: 0机构: Shandong Mingren Freda Pharmaceut Co Ltd, Shandong Prov Engn Res Ctr Med Orthoped Pain, Jinan 250104, Peoples R China Univ Jinan, Sch Biol Sci & Technol, Jinan 250012, Peoples R ChinaFang, Lei论文数: 0 引用数: 0 h-index: 0机构: Univ Jinan, Sch Biol Sci & Technol, Jinan 250012, Peoples R China Univ Jinan, Sch Biol Sci & Technol, Jinan 250012, Peoples R China
- [3] Antitumor quinazoline alkaloids from the seeds of Peganum harmalaJOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2015, 17 (05) : 595 - 600Wang, Chun-Hua论文数: 0 引用数: 0 h-index: 0机构: Wuhan Univ, Sch Pharmaceut Sci, Wuhan 430071, Peoples R China Wuhan Univ, Sch Pharmaceut Sci, Wuhan 430071, Peoples R ChinaZeng, Hong论文数: 0 引用数: 0 h-index: 0机构: Xinjiang Prod & Construct Corps Key Lab Protect &, Tarim 843300, Peoples R China Wuhan Univ, Sch Pharmaceut Sci, Wuhan 430071, Peoples R ChinaWang, Yi-Hai论文数: 0 引用数: 0 h-index: 0机构: Guangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Guangdong, Peoples R China Wuhan Univ, Sch Pharmaceut Sci, Wuhan 430071, Peoples R ChinaLi, Chuan论文数: 0 引用数: 0 h-index: 0机构: Guangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Guangdong, Peoples R China Wuhan Univ, Sch Pharmaceut Sci, Wuhan 430071, Peoples R ChinaCheng, Jun论文数: 0 引用数: 0 h-index: 0机构: Guangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Guangdong, Peoples R China Wuhan Univ, Sch Pharmaceut Sci, Wuhan 430071, Peoples R ChinaYe, Zhi-Jun论文数: 0 引用数: 0 h-index: 0机构: Guangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Guangdong, Peoples R China Wuhan Univ, Sch Pharmaceut Sci, Wuhan 430071, Peoples R ChinaHe, Xiang-Jiu论文数: 0 引用数: 0 h-index: 0机构: Wuhan Univ, Sch Pharmaceut Sci, Wuhan 430071, Peoples R China Guangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Guangdong, Peoples R China Wuhan Univ, Sch Pharmaceut Sci, Wuhan 430071, Peoples R China
- [4] Cytotoxicity of alkaloids isolated from Peganum harmala seedsPAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2013, 26 (04) : 699 - 706Lamchouri, Fatima论文数: 0 引用数: 0 h-index: 0机构: Fac Polydisciplinaire Taza, Equipe Rech Subst Nat & Environm, Taza, Morocco Fac Polydisciplinaire Taza, Equipe Rech Subst Nat & Environm, Taza, MoroccoZemzami, Mustapha论文数: 0 引用数: 0 h-index: 0机构: Domaine Agr Maamora, UCP, Sale, Morocco Fac Polydisciplinaire Taza, Equipe Rech Subst Nat & Environm, Taza, MoroccoJossang, Akino论文数: 0 引用数: 0 h-index: 0机构: Museum Natl Hist Nat Paris, Lab Chim Subst Nat, Paris, France Fac Polydisciplinaire Taza, Equipe Rech Subst Nat & Environm, Taza, MoroccoSettaf, Abdellatif论文数: 0 引用数: 0 h-index: 0机构: Fac Med & Pharm Rabat, Lab Pharmacol & Toxicol, Rabat, Morocco Fac Polydisciplinaire Taza, Equipe Rech Subst Nat & Environm, Taza, MoroccoIsraili, Zafar H.论文数: 0 引用数: 0 h-index: 0机构: Emory Univ, Sch Med, Dept Med, Atlanta, GA USA Fac Polydisciplinaire Taza, Equipe Rech Subst Nat & Environm, Taza, MoroccoLyoussi, Badiaa论文数: 0 引用数: 0 h-index: 0机构: Fac Sci, Lab Physiol Pharmacol & Sante Environm, Fes, Morocco Fac Polydisciplinaire Taza, Equipe Rech Subst Nat & Environm, Taza, Morocco
- [5] Racemic indole alkaloids from the seeds of Peganum harmalaFITOTERAPIA, 2018, 125 : 155 - 160Wang, Kai-Bo论文数: 0 引用数: 0 h-index: 0机构: Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Liaoning, Peoples R China Purdue Univ, Coll Pharm, Dept Med Chem & Mol Pharmacol, W Lafayette, IN 47907 USA Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Liaoning, Peoples R ChinaHu, Xu论文数: 0 引用数: 0 h-index: 0机构: Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Liaoning, Peoples R China Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Liaoning, Peoples R ChinaLi, Sheng-Ge论文数: 0 引用数: 0 h-index: 0机构: Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Liaoning, Peoples R China Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Liaoning, Peoples R ChinaLi, Xin-Yu论文数: 0 引用数: 0 h-index: 0机构: Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Liaoning, Peoples R China Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Liaoning, Peoples R ChinaLi, Da-Hong论文数: 0 引用数: 0 h-index: 0机构: Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Liaoning, Peoples R China Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Liaoning, Peoples R ChinaBai, Jiao论文数: 0 引用数: 0 h-index: 0机构: Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Liaoning, Peoples R China Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Liaoning, Peoples R ChinaPei, Yue-Hu论文数: 0 引用数: 0 h-index: 0机构: Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Liaoning, Peoples R China Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Liaoning, Peoples R ChinaLi, Zhan-Lin论文数: 0 引用数: 0 h-index: 0机构: Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Liaoning, Peoples R China Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Liaoning, Peoples R ChinaHua, Hui-Ming论文数: 0 引用数: 0 h-index: 0机构: Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Liaoning, Peoples R China Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Liaoning, Peoples R China
- [6] Alkaloids from the entheogenic plant Peganum harmalaAUSTRALIAN JOURNAL OF CHEMISTRY, 2023, 76 (05) : 264 - 278Anstis, Daniel G.论文数: 0 引用数: 0 h-index: 0机构: Univ Auckland, Sch Chem Sci, 23 Symonds St, Auckland, New Zealand Univ Auckland, Sch Chem Sci, 23 Symonds St, Auckland, New ZealandLiyu, Jessica论文数: 0 引用数: 0 h-index: 0机构: Univ Auckland, Sch Chem Sci, 23 Symonds St, Auckland, New Zealand Univ Auckland, Sch Chem Sci, 23 Symonds St, Auckland, New ZealandDavison, Emma K.论文数: 0 引用数: 0 h-index: 0机构: Univ Auckland, Sch Chem Sci, 23 Symonds St, Auckland, New Zealand Univ Auckland, Sch Chem Sci, 23 Symonds St, Auckland, New ZealandSperry, Jonathan论文数: 0 引用数: 0 h-index: 0机构: Univ Auckland, Sch Chem Sci, 23 Symonds St, Auckland, New Zealand Univ Auckland, Sch Chem Sci, 23 Symonds St, Auckland, New Zealand
- [7] Alkaloids from the seeds of Peganum harmala showing antiplasmodial and vasorelaxant activitiesJOURNAL OF NATURAL MEDICINES, 2008, 62 (04) : 470 - 472Astulla, Adil论文数: 0 引用数: 0 h-index: 0机构: Hoshi Univ, Fac Pharmaceut Sci, Shinagawa Ku, Tokyo 1428501, Japan Hoshi Univ, Fac Pharmaceut Sci, Shinagawa Ku, Tokyo 1428501, JapanZaima, Kazumasa论文数: 0 引用数: 0 h-index: 0机构: Hoshi Univ, Fac Pharmaceut Sci, Shinagawa Ku, Tokyo 1428501, Japan Hoshi Univ, Fac Pharmaceut Sci, Shinagawa Ku, Tokyo 1428501, JapanMatsuno, Yosuke论文数: 0 引用数: 0 h-index: 0机构: Hoshi Univ, Fac Pharmaceut Sci, Shinagawa Ku, Tokyo 1428501, Japan Hoshi Univ, Fac Pharmaceut Sci, Shinagawa Ku, Tokyo 1428501, JapanHirasawa, Yusuke论文数: 0 引用数: 0 h-index: 0机构: Hoshi Univ, Fac Pharmaceut Sci, Shinagawa Ku, Tokyo 1428501, Japan Hoshi Univ, Fac Pharmaceut Sci, Shinagawa Ku, Tokyo 1428501, JapanEkasari, Wiwied论文数: 0 引用数: 0 h-index: 0机构: Airlangga Univ, Fac Pharm, Jalan Dharmawangsa Dalam 60286, Surabaya, Indonesia Hoshi Univ, Fac Pharmaceut Sci, Shinagawa Ku, Tokyo 1428501, JapanWidyawaruyanti, Aty论文数: 0 引用数: 0 h-index: 0机构: Airlangga Univ, Fac Pharm, Jalan Dharmawangsa Dalam 60286, Surabaya, Indonesia Hoshi Univ, Fac Pharmaceut Sci, Shinagawa Ku, Tokyo 1428501, JapanZaini, Noor Cholies论文数: 0 引用数: 0 h-index: 0机构: Airlangga Univ, Fac Pharm, Jalan Dharmawangsa Dalam 60286, Surabaya, Indonesia Hoshi Univ, Fac Pharmaceut Sci, Shinagawa Ku, Tokyo 1428501, JapanMorita, Hiroshi论文数: 0 引用数: 0 h-index: 0机构: Hoshi Univ, Fac Pharmaceut Sci, Shinagawa Ku, Tokyo 1428501, Japan Hoshi Univ, Fac Pharmaceut Sci, Shinagawa Ku, Tokyo 1428501, Japan
- [8] Alkaloids of Peganum harmalaCHEMISTRY OF NATURAL COMPOUNDS, 2000, 36 (06) : 602 - 605Faskhutdinov, MF论文数: 0 引用数: 0 h-index: 0机构: Acad Sci Republ Uzbekistan, S Yu Yunusov Inst Chem Plant Subst, Tashkent, Uzbekistan Acad Sci Republ Uzbekistan, S Yu Yunusov Inst Chem Plant Subst, Tashkent, UzbekistanTelezhenetskaya, MV论文数: 0 引用数: 0 h-index: 0机构: Acad Sci Republ Uzbekistan, S Yu Yunusov Inst Chem Plant Subst, Tashkent, Uzbekistan Acad Sci Republ Uzbekistan, S Yu Yunusov Inst Chem Plant Subst, Tashkent, UzbekistanLevkovich, MG论文数: 0 引用数: 0 h-index: 0机构: Acad Sci Republ Uzbekistan, S Yu Yunusov Inst Chem Plant Subst, Tashkent, Uzbekistan Acad Sci Republ Uzbekistan, S Yu Yunusov Inst Chem Plant Subst, Tashkent, UzbekistanAbdullaev, ND论文数: 0 引用数: 0 h-index: 0机构: Acad Sci Republ Uzbekistan, S Yu Yunusov Inst Chem Plant Subst, Tashkent, Uzbekistan Acad Sci Republ Uzbekistan, S Yu Yunusov Inst Chem Plant Subst, Tashkent, Uzbekistan
- [9] Alkaloids of Peganum harmalaChemistry of Natural Compounds, 2000, 36 : 602 - 605M. F. Faskhutdinov论文数: 0 引用数: 0 h-index: 0机构: Academy of Sciences of the Republic of Uzbekistan,S.Yu. Yunusov Institute of the Chemistry of Plant SubstancesM. V. Telezhenetskaya论文数: 0 引用数: 0 h-index: 0机构: Academy of Sciences of the Republic of Uzbekistan,S.Yu. Yunusov Institute of the Chemistry of Plant SubstancesM. G. Levkovich论文数: 0 引用数: 0 h-index: 0机构: Academy of Sciences of the Republic of Uzbekistan,S.Yu. Yunusov Institute of the Chemistry of Plant SubstancesN. D. Abdullaev论文数: 0 引用数: 0 h-index: 0机构: Academy of Sciences of the Republic of Uzbekistan,S.Yu. Yunusov Institute of the Chemistry of Plant Substances
- [10] Anti-tumor alkaloids from Peganum harmalaPHYTOCHEMISTRY, 2022, 197Zhang, Qin论文数: 0 引用数: 0 h-index: 0机构: Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Peoples R China Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Peoples R ChinaZan, Yan-Hui论文数: 0 引用数: 0 h-index: 0机构: Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Peoples R China Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Peoples R ChinaYang, Han-Gao论文数: 0 引用数: 0 h-index: 0机构: Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Peoples R China Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Peoples R ChinaYang, Meng-Yue论文数: 0 引用数: 0 h-index: 0机构: Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Peoples R China Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Peoples R ChinaLiu, Fang-Shen论文数: 0 引用数: 0 h-index: 0机构: Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Peoples R China Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Peoples R ChinaLi, Sheng-Ge论文数: 0 引用数: 0 h-index: 0机构: Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Peoples R China Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Peoples R ChinaPeng, Xiao-Hui论文数: 0 引用数: 0 h-index: 0机构: Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Peoples R China Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Peoples R ChinaLin, Bin论文数: 0 引用数: 0 h-index: 0机构: Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, Shenyang 110016, Liaoning, Peoples R China Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Peoples R ChinaLi, Zhan-Lin论文数: 0 引用数: 0 h-index: 0机构: Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Peoples R China Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Peoples R ChinaLi, Da-Hong论文数: 0 引用数: 0 h-index: 0机构: Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Peoples R China Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Peoples R ChinaHua, Hui-Ming论文数: 0 引用数: 0 h-index: 0机构: Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Peoples R China Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Peoples R China