A simple and convenient route for the synthesis of isoxazol-5(4H)-one H )-one derivatives is described via multi-component condensation of aryl aldehyde, ethyl acetoacetate and hydroxyl amine under the influence of 1-butyl-3-methyl-imidazolium hexafluoro phosphate [BMIM][PF6] 6 ] ionic liquid as an efficient, cheaper and eco-friendly catalyst under conventional reflux condition in ethanol. The present protocol has several beneficial things such as simple work-up process, a cleaner reaction, optimum reaction time and good to excellent yields.
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Zhang Y. N., 2011, Bull. Korean Chem. Soc., V32, P3559