Immune Microenvironment in Gallbladder Adenocarcinomas

被引:3
作者
Patil, Pallavi A. [1 ,4 ]
Lombardo, Kara [5 ]
Cao, Weibiao [2 ,3 ]
机构
[1] Brown Univ, Rhode Isl Hosp, Dept Pathol, Providence, RI 02903 USA
[2] Brown Univ, Rhode Isl Hosp, Dept Pathol & Med, 593 Eddy St,APC12, Providence, RI 02903 USA
[3] Brown Univ, Alpert Med Sch, Providence, RI 02903 USA
[4] USA Hlth Univ Hosp, Mobile, AL USA
[5] Johns Hopkins Univ Hosp, Dept Pathol, Baltimore, MD USA
关键词
immune microenvironment; gallbladder; adenocarcinoma; programmed death ligand 1; PD-L1; tumor infiltrating lymphocytes; programmed death-1; PD1; SOLID TUMORS; CARCINOMA; CANCER; EXPRESSION; BLOCKADE;
D O I
10.1097/PAI.0000000000000922
中图分类号
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号
100101 ;
摘要
Programmed death-1 (PD1) expression has not been reported in gallbladder adenocarcinoma. In this study we examined PD1 expression in gallbladder cancer to explore the correlation between PD1 expression and the clinicopathologic parameters. We found that 98% (46/47) cases expressed programmed death-ligand 1 (PD-L1) with 85% cases being PD-L1 3+. PD1+ tumor-infiltrating lymphocytes (TILs) were present in 78.7% cases (37/47). The tumor size was significantly smaller and the stromal CD3+ TILs were significantly higher in tumors with PD1+ TILs than those with PD1- TILs. In the tumors with size of <3 cm, stromal CD3+ TILs >115/HPF or stromal CD8+ TILs >45/HPF were associated with much better survival than those with stromal CD3+ TILs <= 115/HPF or stromal CD8+ TILs <= 45/HPF. In tumors with the size of 3 cm or larger, PD1+ TILs or stromal CD8+ TILs >45/HPF carried a significantly poorer survival than PD1- tumors or stromal CD8+ TILs <=45/HPF. No correlation was identified between PD1 expression and lymphovascular invasion, distant metastasis, pathologic tumor stage or prognostic stage. Multivariate survival analysis showed that tumor TNM stage and age were independent prognostic factors in gallbladder adenocarcinomas. We conclude that gallbladder adenocarcinomas may have high PD-L1 expression and PD1+ TILs. Smaller tumor size and greater amount of stromal CD3+ T cells were found in tumors with PD1+ TILs. In small tumors (<3 cm), high stromal CD3+ TILs or high stromal CD8+ TILs were associated with better survival. However, in large tumors (>= 3 cm), PD1+ TILs or high stromal CD8+ TILs carried a poorer survival. Our study implied that immune-based therapy including PD1/PD-L1 checkpoint blockade might be useful in gallbladder adenocarcinomas.
引用
收藏
页码:557 / 563
页数:7
相关论文
共 50 条
  • [41] The immune microenvironment of breast ductal carcinoma in situ
    Thompson, Elizabeth
    Taube, Janis M.
    Elwood, Hillary
    Sharma, Rajni
    Meeker, Alan
    Warzecha, Hind Nassar
    Argani, Pedram
    Cimino-Mathews, Ashley
    Emens, Leisha A.
    MODERN PATHOLOGY, 2016, 29 (03) : 249 - 258
  • [42] Prognostic Significance of the Immune Microenvironment in Endometrial Cancer
    Lee, Miseon
    Jung, Wonkyung
    Kang, Jeongseok
    Lee, Keun Ho
    Lee, Sung Jong
    Hong, Sook Hee
    Kang, Jun
    Lee, Ahwon
    LABORATORY INVESTIGATION, 2024, 104 (09)
  • [43] Resistance to immune checkpoint inhibitors and the tumor microenvironment
    Kawashima, Shusuke
    Togashi, Yosuke
    EXPERIMENTAL DERMATOLOGY, 2023, 32 (03) : 240 - 249
  • [44] Immune Features of Tumor Microenvironment: A Genetic Spotlight
    Asadi, Milad
    Zarredar, Habib
    Zafari, Venus
    Soleimani, Zahra
    Saeedi, Hossein
    Caner, Ayse
    Shanehbandi, Dariush
    CELL BIOCHEMISTRY AND BIOPHYSICS, 2024, 82 (01) : 107 - 118
  • [45] Co-dependencies in the tumor immune microenvironment
    Chen, Peiwen
    Dey, Prasenjit
    ONCOGENE, 2022, 41 (31) : 3821 - 3829
  • [46] Impact of spatial metabolomics on immune-microenvironment in oral cancer prognosis: a clinical report
    Bag, Swarnendu
    Oetjen, Janina
    Shaikh, Soni
    Chaudhary, Amrita
    Arun, Pattatheyil
    Mukherjee, Geetashree
    MOLECULAR AND CELLULAR BIOCHEMISTRY, 2024, 479 (01) : 41 - 49
  • [47] Characterization of the tumor immune-microenvironment of lung adenocarcinoma associated with usual interstitial pneumonia
    Ueda, Takuya
    Aokage, Keiju
    Mimaki, Sachiyo
    Tane, Kenta
    Miyoshi, Tomohiro
    Sugano, Masato
    Kojima, Motohiro
    Fujii, Satoshi
    Kuwata, Takeshi
    Ochiai, Atsushi
    Kusumoto, Masahiko
    Suzuki, Kenji
    Tsuchihara, Katsuya
    Nishikawa, Hiroyoshi
    Goto, Koichi
    Tsuboi, Masahiro
    Ishii, Genichiro
    LUNG CANCER, 2018, 126 : 162 - 169
  • [48] Clinical Impact of the Immune Microenvironment in Spinal Chordoma: Immunoscore as an Independent Favorable Prognostic Factor
    Zou, Ming-Xiang
    Lv, Guo-Hua
    Wang, Xiao-Bin
    Huang, Wei
    Li, Jing
    Jiang, Yi
    She, Xiao-Ling
    NEUROSURGERY, 2019, 84 (06) : E318 - E333
  • [49] Program Death 1 Immune Checkpoint and Tumor Microenvironment: Implications for Patients With Intrahepatic Cholangiocarcinoma
    Gani, Faiz
    Nagarajan, Neeraja
    Kim, Yuhree
    Zhu, Qingfeng
    Luan, Lan
    Bhaijjee, Feriyl
    Anders, Robert A.
    Pawlik, Timothy M.
    ANNALS OF SURGICAL ONCOLOGY, 2016, 23 (08) : 2610 - 2617
  • [50] Comparison of the tumor immune microenvironment phenotypes in different breast cancers after neoadjuvant therapy
    Han, Mengxue
    Li, Jinze
    Wu, Si
    Wu, Chun
    Yu, Yongqiang
    Liu, Yueping
    CANCER MEDICINE, 2023, 12 (03): : 2906 - 2917