Immune Microenvironment in Gallbladder Adenocarcinomas
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作者:
Patil, Pallavi A.
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Brown Univ, Rhode Isl Hosp, Dept Pathol, Providence, RI 02903 USA
USA Hlth Univ Hosp, Mobile, AL USABrown Univ, Rhode Isl Hosp, Dept Pathol, Providence, RI 02903 USA
Patil, Pallavi A.
[1
,4
]
Lombardo, Kara
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Johns Hopkins Univ Hosp, Dept Pathol, Baltimore, MD USABrown Univ, Rhode Isl Hosp, Dept Pathol, Providence, RI 02903 USA
Lombardo, Kara
[5
]
Cao, Weibiao
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Brown Univ, Rhode Isl Hosp, Dept Pathol & Med, 593 Eddy St,APC12, Providence, RI 02903 USA
Brown Univ, Alpert Med Sch, Providence, RI 02903 USABrown Univ, Rhode Isl Hosp, Dept Pathol, Providence, RI 02903 USA
Cao, Weibiao
[2
,3
]
机构:
[1] Brown Univ, Rhode Isl Hosp, Dept Pathol, Providence, RI 02903 USA
[2] Brown Univ, Rhode Isl Hosp, Dept Pathol & Med, 593 Eddy St,APC12, Providence, RI 02903 USA
[3] Brown Univ, Alpert Med Sch, Providence, RI 02903 USA
[4] USA Hlth Univ Hosp, Mobile, AL USA
[5] Johns Hopkins Univ Hosp, Dept Pathol, Baltimore, MD USA
Programmed death-1 (PD1) expression has not been reported in gallbladder adenocarcinoma. In this study we examined PD1 expression in gallbladder cancer to explore the correlation between PD1 expression and the clinicopathologic parameters. We found that 98% (46/47) cases expressed programmed death-ligand 1 (PD-L1) with 85% cases being PD-L1 3+. PD1+ tumor-infiltrating lymphocytes (TILs) were present in 78.7% cases (37/47). The tumor size was significantly smaller and the stromal CD3+ TILs were significantly higher in tumors with PD1+ TILs than those with PD1- TILs. In the tumors with size of <3 cm, stromal CD3+ TILs >115/HPF or stromal CD8+ TILs >45/HPF were associated with much better survival than those with stromal CD3+ TILs <= 115/HPF or stromal CD8+ TILs <= 45/HPF. In tumors with the size of 3 cm or larger, PD1+ TILs or stromal CD8+ TILs >45/HPF carried a significantly poorer survival than PD1- tumors or stromal CD8+ TILs <=45/HPF. No correlation was identified between PD1 expression and lymphovascular invasion, distant metastasis, pathologic tumor stage or prognostic stage. Multivariate survival analysis showed that tumor TNM stage and age were independent prognostic factors in gallbladder adenocarcinomas. We conclude that gallbladder adenocarcinomas may have high PD-L1 expression and PD1+ TILs. Smaller tumor size and greater amount of stromal CD3+ T cells were found in tumors with PD1+ TILs. In small tumors (<3 cm), high stromal CD3+ TILs or high stromal CD8+ TILs were associated with better survival. However, in large tumors (>= 3 cm), PD1+ TILs or high stromal CD8+ TILs carried a poorer survival. Our study implied that immune-based therapy including PD1/PD-L1 checkpoint blockade might be useful in gallbladder adenocarcinomas.
机构:
Lunit, Dept Oncol, Seoul, South KoreaCatholic Univ Korea, Dept Hosp Pathol, Seoul St Marys Hosp, Coll Med, Seoul, South Korea
Jung, Wonkyung
Kang, Jeongseok
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Lunit, Dept Oncol, Seoul, South KoreaCatholic Univ Korea, Dept Hosp Pathol, Seoul St Marys Hosp, Coll Med, Seoul, South Korea
Kang, Jeongseok
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Lee, Keun Ho
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Lee, Sung Jong
Hong, Sook Hee
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机构:
Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Internal Med,Div Oncol, Seoul, South KoreaCatholic Univ Korea, Dept Hosp Pathol, Seoul St Marys Hosp, Coll Med, Seoul, South Korea
机构:
Lunit, Dept Oncol, Seoul, South KoreaCatholic Univ Korea, Dept Hosp Pathol, Seoul St Marys Hosp, Coll Med, Seoul, South Korea
Jung, Wonkyung
Kang, Jeongseok
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Lunit, Dept Oncol, Seoul, South KoreaCatholic Univ Korea, Dept Hosp Pathol, Seoul St Marys Hosp, Coll Med, Seoul, South Korea
Kang, Jeongseok
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Lee, Keun Ho
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Lee, Sung Jong
Hong, Sook Hee
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Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Internal Med,Div Oncol, Seoul, South KoreaCatholic Univ Korea, Dept Hosp Pathol, Seoul St Marys Hosp, Coll Med, Seoul, South Korea