Molecular insights into the inhibition of proton-activated chloride channel by transfer RNA

被引:0
|
作者
Chi, Pengliang [1 ]
Wang, Xiang [1 ]
Li, Jialu [1 ]
Yang, Hui [2 ]
Li, Kaiju [1 ,3 ,4 ]
Zhang, Yuqi [5 ]
Lin, Shiyi [5 ]
Yu, Leiye [6 ,7 ]
Liu, Shiqi [2 ]
Chen, Lu [1 ]
Ren, Ruobing [6 ,7 ]
Wu, Jianping [5 ]
Huang, Zhuo [2 ]
Geng, Jia [3 ,4 ]
Deng, Dong [1 ,8 ]
机构
[1] Sichuan Univ, West China Hosp 2, Dept Obstet,State Key Lab Biotherapy, Key Lab Birth Defects & Related Dis Women & Childr, Chengdu, Sichuan, Peoples R China
[2] Peking Univ, Sch Pharmaceut Sci, Dept Mol & Cellular Pharmacol, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
[3] Sichuan Univ, West China Hosp, Dept Lab Med, Chengdu, Sichuan, Peoples R China
[4] Collaborat Innovat Ctr Biotherapy, Chengdu, Sichuan, Peoples R China
[5] Westlake Univ, Sch Life Sci, Key Lab Struct Biol Zhejiang Prov, Westlake Lab Life Sci & Biomed, Hangzhou 310024, Zhejiang, Peoples R China
[6] Chinese Univ Hong Kong, Kobilka Inst Innovat Drug Discovery, Sch Life & Hlth Sci, Shenzhen 518172, Guangdong, Peoples R China
[7] Fudan Univ, Inst Metab & Integrat Biol, Shanghai Key Lab Metab Remodeling & Hlth, Shanghai, Peoples R China
[8] Sichuan Univ, Dev & Related Dis Women & Children Key Lab Sichuan, Chengdu, Sichuan, Peoples R China
基金
中国国家自然科学基金;
关键词
PROTEIN; PAC;
D O I
10.1038/s41422-024-00993-6
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
引用
收藏
页码:743 / 745
页数:3
相关论文
共 50 条
  • [21] Proton-Activated Chloride Channel Enhances Endplate Porous Osteoclast Resorption to Induce Spinal Pain
    Zhang, Weixin
    Xue, Peng
    Wang, Shenyu
    Chu, Jiachen
    Crane, Janet
    Wan, Mei
    Qiu, Zhaozhu
    Cao, Xu
    JOURNAL OF BONE AND MINERAL RESEARCH, 2023, 38 : 53 - 53
  • [22] A Novel Proton-Activated Chloride Channel Regulates Osteoclast Fusion for Spine Endplate Porosity and Pain
    Zhang, Weixin
    Xue, Peng
    Yang, Junhua
    Chu, Jiachen
    Wan, Mei
    Zheng, Junying
    Qiu, Zhaozhu
    Cao, Xu
    JOURNAL OF BONE AND MINERAL RESEARCH, 2024, 39 : 41 - 41
  • [23] Characterization of a proton-activated, outwardly rectifying anion channel
    Lambert, S
    Oberwinkler, J
    JOURNAL OF PHYSIOLOGY-LONDON, 2005, 567 (01): : 191 - 213
  • [24] Proton-activated chloride channel increases endplate porosity and pain in a mouse spine degeneration model
    Xue, Peng
    Zhang, Weixin
    Shen, Mengxi
    Yang, Junhua
    Chu, Jiachen
    Wang, Shenyu
    Wan, Mei
    Zheng, Junying
    Qiu, Zhaozhu
    Cao, Xu
    JOURNAL OF CLINICAL INVESTIGATION, 2024, 134 (20):
  • [25] Structures of Human Proton-Activated Chloride Channel (PAC) Reveal Mechanism of pH Sensing and Gating
    Osei-Owusu, James
    Ruan, Zheng
    Du, Juan
    Lu, Wei
    Qiu, Zhaozhu
    BIOPHYSICAL JOURNAL, 2021, 120 (03) : 192A - 192A
  • [26] The role of proton-activated chloride channel 1 (PACC1) in bacterial pneumonia and sepsis
    Garo, Lucien
    Brueck, Kevin
    Strueve, Marcel
    Walachowski, Sarah
    Xu, Shuang
    Helmkamp, Matthew
    Bosmann, Markus
    JOURNAL OF IMMUNOLOGY, 2024, 212 (01):
  • [27] Proton-Activated Chloride Channel Enhances Endplate Porous Osteoclast Resorption to Induce Spinal Pain
    Zhang, Weixin
    Xue, Peng
    Wang, Shenyu
    Chu, Jiachen
    Crane, Janet
    Wan, Mei
    Qiu, Zhaozhu
    Cao, Xu
    JOURNAL OF BONE AND MINERAL RESEARCH, 2023, 38 : 335 - 336
  • [28] Proton-activated chloride channel PAC regulates endosomal acidification and transferrin receptor-mediated endocytosis
    Osei-Owusu, James
    Yang, Junhua
    Leung, Ka Ho
    Ruan, Zheng
    Lu, Wei
    Krishnan, Yamuna
    Qiu, Zhaozhu
    CELL REPORTS, 2021, 34 (04):
  • [29] Development of Small-Molecule Inhibitors of Proton-Activated Chloride Channels
    Figueroa, Eric E.
    Denton, Jerod S.
    BIOPHYSICAL JOURNAL, 2020, 118 (03) : 590A - 590A
  • [30] Identification of the Acid-Sensitive Site Critical for Chloral Hydrate (CH) Activation of the Proton-Activated Chloride Channel
    Xu, Xiang-Ying
    Zhang, Fei-Fei
    Gan, Jun
    Zhang, Mao-Yin
    Shen, Zhong-Shan
    Guo, Qing
    Teng, Yue
    Ji, Jun-Wei
    Cao, Jun -Li
    Tang, Qiong-Yao
    Zhang, Zhe
    JOURNAL OF NEUROSCIENCE, 2023, 43 (04): : 526 - 539