The Antimicrobial Potency of Mesoporous Silica Nanoparticles Loaded with Melissa officinalis Extract

被引：10

作者：

Petrisor, Gabriela ^{[1
,2
,3
,4
]}

Motelica, Ludmila ^{[1
,2
,3
,4
]}

Trusca, Roxana Doina ^{[1
,2
,3
]}

Mirt, Andreea-Luiza ^{[1
,2
,3
,5
]}

Vasilievici, Gabriel ^{[5
]}

Tomescu, Justinian-Andrei ^{[6
]}

Manea, Cristina ^{[6
]}

Dumbrava, Andreea Stefania ^{[7
]}

Corbu, Viorica Maria ^{[7
]}

Gheorghe-Barbu, Irina ^{[7
]}

Ficai, Denisa ^{[2
,3
,4
,8
]}

Oprea, Ovidiu-Cristian ^{[2
,3
,4
,8
]}

Vasile, Bogdan-Stefan ^{[1
,2
,3
,4
]}

Ficai, Anton ^{[1
,2
,3
,4
]}

Raiciu, Anca Daniela ^{[6
,9
]}

机构：

[1] Natl Univ Sci & Technol POLITEHN Bucharest, Fac Chem Engn & Biotechnol, Sci & Engn Oxide Mat & Nanomat, Gh Polizu 1-7, Bucharest 011061, Romania

[2] Natl Univ Sci & Technol POLITEHN Bucharest, Natl Ctr Sci Res Food Safety, Splaiul Independentei 313, Bucharest 060042, Romania

[3] Natl Univ Sci & Technol POLITEHN Bucharest, Natl Ctr Micro & Nanomat, Splaiul Independentei 313, Bucharest 060042, Romania

[4] Acad Romanian Scientists, Bucharest 050044, Romania

[5] Natl Inst Res Dev Chem & Petrochem ICECHIM, Spl Independentei 202, Bucharest 060021, Romania

[6] SC Hofigal Export Import SA, Intrarea Serelor 2, Bucharest 042124, Romania

[7] Univ Bucharest, Fac Biol, 1-3 Aleea Portocalelor, Bucharest 060101, Romania

[8] Natl Univ Sci & Technol POLITEHN Bucharest, Fac Chem Engn & Biotechnol, Dept Inorgan Chem Phys Chem & Elect, Gh Polizu 1-7, Bucharest 011061, Romania

[9] Titu Maiorescu Univ, Dept Pharmacognosy Phytochem Phytoterapy, Fac Pharm, Gh Sincai 16, Bucharest 040405, Romania

来源：

PHARMACEUTICS | 2024年 / 16卷 / 04期

关键词：

Melissa officinalis; MCM-41; MCM-48; APTES; antimicrobial activity; hydroalcoholic extract; methicillin-resistant S. aureus; MRSA; ANTIOXIDANT ACTIVITY; IN-VITRO; PLANTS;

D O I：

10.3390/pharmaceutics16040525

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Melissa officinalis is an important medicinal plant that is used and studied intensively due to its numerous pharmacological effects. This plant has numerous active compounds with biomedical potential; some are volatile, while others are sensitive to heat or oxygen. Therefore, to increase stability and prolong biological activities, the natural extract can be loaded into various nanostructured systems. In this study, different loading systems were obtained from mesoporous silica, like Mobile Composition of Matter family (MCM) with a hexagonal (MCM-41) or cubic (MCM-48) pore structure, simple or functionalized with amino groups (using 3-aminopropyl) such as triethoxysilane (APTES). Thus, the four materials were characterized from morphological and structural points of view by scanning electron microscopy, a BET analysis with adsorption-desorption isotherms, Fourier-transform infrared spectroscopy (FTIR) and a thermogravimetric analysis coupled with differential scanning calorimetry. Natural extract from Melissa officinalis was concentrated and analyzed by High-Performance Liquid Chromatography to identify the polyphenolic compounds. The obtained materials were tested against Gram-negative bacteria and yeasts and against both reference strains and clinical strains belonging to Gram-positive bacteria that were previously isolated from intra-hospital infections. The highest antimicrobial efficiency was found against Gram-positive and fungal strains. Good activity was also recorded against methicillin-resistant S. aureus, the Melissa officinalis extract inhibiting the production of various virulence factors.

引用

页数：23