Pharmacotherapeutic Considerations on Telomere Biology: The Positive Effect of Pharmacologically Active Substances on Telomere Length

被引：12

作者：

Apetroaei, Miruna-Maria ^{[1
]}

Fragkiadaki, Persefoni ^{[2
,3
]}

Velescu, Bruno Stefan ^{[1
]}

Baliou, Stella ^{[2
,3
]}

Renieri, Elisavet ^{[2
,3
]}

Dinu-Pirvu, Cristina Elena ^{[1
]}

Draganescu, Doina ^{[1
]}

Vlasceanu, Ana Maria ^{[1
]}

Nedea, Marina Ionela ^{[1
]}

Udeanu, Denisa Ioana ^{[1
]}

Docea, Anca Oana ^{[4
]}

Tsatsakis, Artistidis ^{[2
,3
]}

Arsene, Andreea Letitia ^{[1
]}

机构：

[1] Carol Davila Univ Med & Pharm, Fac Pharm, 6 Traian Vuia St, Bucharest 020956, Romania

[2] Univ Crete, Med Sch, Lab Toxicol & Forens Sci, Voutes 71003, Heraklion, Greece

[3] Lifeplus SA, Sci & Technol Pk Crete, C Bldg, Vassilika Vouton 70013, Heraklion, Greece

[4] Univ Med & Pharm Craiova, Dept Toxicol, Craiova 200349, Romania

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 14期

关键词：

telomere length; ageing; pharmacotherapy; pharmacotherapy on telomeres; anti-senescence drugs; drugs on telomere length; personalised therapy; novel biomarker; OXIDATIVE STRESS; MENDELIAN RANDOMIZATION; POTENTIAL BIOMARKER; CELL-PROLIFERATION; DIABETES-MELLITUS; METFORMIN TARGETS; MONONUCLEAR-CELLS; GLOBAL BURDEN; LIFE-STYLE; MELATONIN;

D O I：

10.3390/ijms25147694

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Telomeres are part of chromatin structures containing repeated DNA sequences, which function as protective caps at the ends of chromosomes and prevent DNA degradation and recombination, thus ensuring the integrity of the genome. While telomere length (TL) can be genetically inherited, TL shortening has been associated with ageing and multiple xenobiotics and bioactive substances. TL has been characterised as a reliable biomarker for the predisposition to developing chronic pathologies and their progression. This narrative review aims to provide arguments in favour of including TL measurements in a complex prognostic and diagnostic panel of chronic pathologies and the importance of assessing the effect of different pharmacologically active molecules on the biology of telomeres. Medicines used in the management of cardiovascular diseases, diabetes, schizophrenia, hormone replacement therapy at menopause, danazol, melatonin, and probiotics have been studied for their positive protective effects against TL shortening. All these classes of drugs are analysed in the present review, with a particular focus on the molecular mechanisms involved.

引用

页数：27

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