Protein-protein interactions in cGAS-STING pathway: a medicinal chemistry perspective

被引：1

作者：

Zhang, Shi-Duo ^{[1
,2
]}

Li, Hui ^{[1
,2
]}

Zhou, Ye-Ling ^{[1
,2
]}

Liu, Xue-Chun ^{[1
,2
]}

Li, De-Chang ^{[1
,2
]}

Hao, Chuan-Feng ^{[1
,2
]}

You, Qi-Dong ^{[1
,2
]}

Xu, Xiao-Li ^{[1
,2
]}

机构：

[1] China Pharmaceut Univ, State Key Lab Nat Med, Jiang Su Key Lab Drug Design & Optimizat, Nanjing 210009, Peoples R China

[2] China Pharmaceut Univ, Sch Pharm, Dept Med Chem, Nanjing 210009, Peoples R China

来源：

FUTURE MEDICINAL CHEMISTRY | 2024年 / 16卷 / 17期

基金：

中国国家自然科学基金;

关键词：

cGAS-STING signaling pathway; drug discovery; innate immunity; modulators; protein-protein interactions; CYCLIC GMP-AMP; EXONUCLEASE TREX1; CRYSTAL-STRUCTURE; STRUCTURAL BASIS; DNA-BINDING; ACTIVATION; SYNTHASE; PROMOTES; SENSOR; MECHANISM;

D O I：

10.1080/17568919.2024.2383164

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Protein-protein interactions (PPIs) play pivotal roles in biological processes and are closely linked with human diseases. Research on small molecule inhibitors targeting PPIs provides valuable insights and guidance for novel drug development. The cGAS-STING pathway plays a crucial role in regulating human innate immunity and is implicated in various pathological conditions. Therefore, modulators of the cGAS-STING pathway have garnered extensive attention. Given that this pathway involves multiple PPIs, modulating PPIs associated with the cGAS-STING pathway has emerged as a promising strategy for modulating this pathway. In this review, we summarize an overview of recent advancements in medicinal chemistry insights into cGAS-STING PPI-based modulators and propose alternative strategies for further drug discovery based on the cGAS-STING pathway.

引用

页码：1801 / 1820

页数：20

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