Recent advances in mesenchymal stem cell therapy for myocardial infarction

被引:1
作者
He, Yu-Chuan [1 ]
Yuan, Guo-Dong [2 ]
Li, Nan [3 ]
Ren, Mei-Fang [2 ]
Qian-Zhang [2 ]
Deng, Kai-Ning [1 ]
Wang, Le-Chuan [1 ]
Xiao, Wei-Ling [1 ]
Ma, Nan [4 ,5 ]
Stamm, Christof [6 ]
Felthaus, Oliver [7 ]
Prantl, Lukas [7 ]
Nie, Jia [2 ]
Wang, Gang [2 ]
机构
[1] Hebei Univ Chinese Med, Grad Sch, Shijiazhuang, Hebei, Peoples R China
[2] Hebei Prov Hosp Chinese Med, Shijiazhuang, Hebei, Peoples R China
[3] Shijiazhuang Obstet & Gynecol Hosp, Shijiazhuang, Hebei, Peoples R China
[4] Helmholtz Zentrum Hereon, Inst Act Polymers, Teltow, Germany
[5] Free Univ Berlin, Inst Chem & Biochem, Berlin, Germany
[6] Deutsch Herzzentrum Berlin, Berlin, Germany
[7] Univ Hosp Regensburg, Dept Plast Hand & Reconstruct Surg, Regensburg, Germany
关键词
Myocardial infarction; mesenchymal stem cells; nanomaterials; GENE DELIVERY; T-CELL; MITOCHONDRIAL TRANSFER; CARDIAC-FUNCTION; STROMAL CELLS; TRANSPLANTATION; HEART; REPAIR; DIFFERENTIATION; EFFICACY;
D O I
10.3233/CH-249101
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Myocardial infarction refers to the ischemic necrosis of myocardium, characterized by a sharp reduction or interruption of blood flow in the coronary arteries due to the coronary artery occlusion, resulting in severe and prolonged ischemia in the corresponding myocardium and ultimately leading to ischemic necrosis of the myocardium. Given its high risk, it is considered as one of the most serious health threats today. In current clinical practice, multiple approaches have been explored to diminish myocardial oxygen consumption and alleviate symptoms, but notable success remains elusive. Accumulated clinical evidence has showed that the implantation of mesenchymal stem cell for treating myocardial infarction is both effective and safe. Nevertheless, there persists controversy and variability regarding the standardizing MSC transplantation protocols, optimizing dosage, and determining the most effective routes of administration. Addressing these remaining issues will pave the way of integration of MSCs as a feasible mainstream cardiac treatment.
引用
收藏
页码:383 / 398
页数:16
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