Compressed air foam has been gradually applied in super high-rise buildings due to its high extinguishing efficiency and great transportation ability. However, the transport characteristics of compressed air foam are unclear because the foam is a complex gas-liquid two-phase fluid. In this study, multi-scale experiments were conducted to investigate the foam properties of compressed air foam and pressure drop in the long-distance vertical pipe. The results show that the foam is compressed as a whole when pressure increases, resulting in a significantly increased foam density. At higher pressures, the bubble coarsening degree decreases, accompanied by a narrower particle size distribution and an increased foam size homogenization. Moreover, a critical pressure phenomenon is observed in foams with different foam expansion ratios. The average foam diameter stabilizes gradually with pressure changes after exceeding the critical pressure. A theoretical model for foam density is developed, considering various pressures, temperatures and foam expansion ratios. When the compressed air foam is transported in the vertical long-distance pipe, the pressure decreases in a slightly downward curve, which is due to the decrease in foam density. Finally, a prediction model for the pressure drop of compressed air foam in the longdistance vertical pipe is proposed, which considers changes in foam density. The accuracy of the prediction model is verified by the multi-scale experimental results. The results deepen the understanding of foam flow in the long-distance vertical pipe and provide useful guidance for applications of compressed air foam in super high-rise buildings.