I2 and aqueous TBHP induced aerial oxidative coupling of 2-aminobenzyl alcohols and nitriles: A novel metal-free route towards quinazolines synthesis

被引：2
作者：
Chetia, Swadhin [1 ]
Nath, Dipankar [1 ]
Purkayastha, Siddhartha K. [2 ]
Guha, Ankur K. [2 ]
Sarma, Diganta [1 ]
机构：
[1] Dibrugarh Univ, Dept Chem, Dibrugarh 786004, Assam, India
[2] Cotton Univ, Adv Computat Chem Ctr, Gauhati 781001, Assam, India
来源：
TETRAHEDRON LETTERS | 2024年 / 142卷
关键词：
Quinazoline; Quinoline; Metal-free; DFT calculations; Radical intermediate; 2-SUBSTITUTED QUINAZOLINES; DEHYDROGENATIVE SYNTHESIS;
D O I：
10.1016/j.tetlet.2024.155084
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of 2-phenylquinazolines were synthesized by using I2/tert-butyl hydroperoxide via oxidative coupling of 2-aminobenzyl alcohols and nitriles. Metal free approach, shorter reaction time, high atom efficiency and scale up synthesis are the salient features of the protocol. Experimental evidence followed by DFT calculations indicate that the reaction pathway of quinazoline formation proceed through radical intermediate.
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页数：4
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