Retinal Perfusion Analysis of Children with Diabetes Mellitus Type 1 Using Optical Coherence Tomography Angiography

被引:0
作者
Vasilijevic, Jelena [1 ,2 ]
Kovacevic, Igor [1 ,2 ]
Polovina, Snezana [3 ]
Dacic-Krnjaja, Bojana [1 ,2 ]
Kalezic, Tanja [1 ,2 ]
Miletic, Suzana [4 ]
Al Barri, Leila [5 ]
Stanca, Simona [6 ]
Ferrari, Francis [7 ]
Jesic, Maja [1 ,8 ]
机构
[1] Univ Belgrade, Fac Med, Belgrade 11000, Serbia
[2] Clin Ctr Serbia, Clin Eye Dis, Belgrade 11000, Serbia
[3] Univ Clin Ctr Serbia, Clin Endocrinol, Belgrade 11000, Serbia
[4] Clin Ctr Kosovska Mitrov, Pediat Clin, Kosovska Mitrovica 38220, Serbia
[5] Victor Babes Univ Med & Pharm, Dept Ophthalmol, Timisoara 300041, Romania
[6] Carol Davila Univ Med & Pharm, Dept Pediat, Bucharest 050474, Romania
[7] Ctr Ophtalmol FUTURA, F-67300 Strasbourg, France
[8] Univ Childrens Hosp, Dept Pediat Endocrinol, Belgrade 11000, Serbia
关键词
retinal perfusion; optical coherence tomography angiography; type; 1; diabetes; vessel density; treatments; RETINOPATHY;
D O I
10.3390/jpm14070696
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
(1) Background: This study aims to evaluate retinal perfusion by optical coherence tomography angiography (OCTA) in pediatric patients with type 1 diabetes mellitus (T1D) without diabetic retinopathy (DR). (2) Methods: Thirty-one patients affected by T1D were enrolled. All participants were evaluated using OCTA. The foveal avascular zone (FAZ) and superficial and deep macular vessel density (VD) were analyzed. The correlation of these parameters with metabolic factors such as body mass index (BMI), glycated hemoglobin (HbA1c), and the type of insulin therapy (multiple daily injections, MDI vs. continuous subcutaneous insulin infusion, CSII) was determined. (3) Results: None of the OCTA parameters were significantly different between the groups. The patients' HbA1C level did not influence any of the OCTA parameters. The use of MDI tended to reduce the parafoveal and perifoveal deep VD (p = 0.048 and p = 0.021, respectively) compared to CSII. An elevated BMI tended to increase the deep macular (p = 0.005) and perifoveal VD (p = 0.006). (4) Conclusion: VD and FAZ are normal in pubescent children with T1D without signs of DR. Treatment with CSII may be a better choice compared to MDI, as CSII may be protective against retinal microvascular damage. Our results indicate the need for new clinical parameters of glycemic control in addition to HbA1c which could assess the risk of DR.
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页数:7
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