JAK Inhibitors in Rheumatoid Arthritis: Immunomodulatory Properties and Clinical Efficacy

被引:7
作者
Kielbowski, Kajetan [1 ]
Plewa, Paulina [2 ]
Bratborska, Aleksandra Wiktoria [3 ]
Bakinowska, Estera [1 ]
Pawlik, Andrzej [1 ]
机构
[1] Pomeranian Med Univ, Dept Physiol, PL-70111 Szczecin, Poland
[2] Univ Szczecin, Inst Biol, PL-71412 Szczecin, Poland
[3] Poznan Univ Med Sci, Dept Internal Med, 60-780 Poznan, Poland
关键词
rheumatoid arthritis; JAK/STAT pathway; JAK inhibitors; COLLAGEN-INDUCED ARTHRITIS; T-CELLS; TOFACITINIB MONOTHERAPY; CP-690,550 TOFACITINIB; ANIMAL-MODELS; BARICITINIB; METHOTREXATE; THERAPY; PLACEBO; ADALIMUMAB;
D O I
10.3390/ijms25158327
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Rheumatoid arthritis (RA) is a highly prevalent autoimmune disorder. The pathogenesis of the disease is complex and involves various cellular populations, including fibroblast-like synoviocytes, macrophages, and T cells, among others. Identification of signalling pathways and molecules that actively contribute to the development of the disease is crucial to understanding the mechanisms involved in the chronic inflammatory environment present in affected joints. Recent studies have demonstrated that the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway regulates the behaviour of immune cells and contributes to the progression of RA. Several JAK inhibitors, such as tofacitinib, baricitinib, upadacitinib, and filgocitinib, have been developed, and their efficacy and safety in patients with RA have been comprehensively investigated in a number of clinical trials. Consequently, JAK inhibitors have been approved and registered as a treatment for patients with RA. In this review, we discuss the involvement of JAK/STAT signalling in the pathogenesis of RA and summarise the potential beneficial effects of JAK inhibitors in cells implicated in the pathogenesis of the disease. Moreover, we present the most important phase 3 clinical trials that evaluated the use of these agents in patients.
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页数:22
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