Indanone: a promising scaffold for new drug discovery against neurodegenerative disorders

被引：2

作者：

Bansal, Ranju ^{[1
]}

Singh, Ranjit ^{[1
]}

Dutta, Tuhin Shubra ^{[1
]}

Dar, Zahid Ahmad ^{[1
]}

Bajpai, Ankit ^{[1
]}

机构：

[1] Panjab Univ, Univ Inst Pharmaceut Sci UIPS, Chandigarh 160014, India

来源：

DRUG DISCOVERY TODAY | 2024年 / 29卷 / 08期

关键词：

indanone; Alzheimer ' s disease; Parkinson ' s disease; monoamine oxidases (MAO); acetylcholinesterase (AChE); molecular docking; TARGETING ALZHEIMERS-DISEASE; ALPHA-TETRALONE DERIVATIVES; MONOAMINE-OXIDASE; ACETYLCHOLINESTERASE INHIBITORS; ANTIINFLAMMATORY DRUGS; PHARMACOLOGICAL EVALUATION; RECEPTOR ANTAGONIST; OXIDATIVE STRESS; ISCHEMIC-STROKE; DESIGN;

D O I：

10.1016/j.drudis.2024.104063

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Indanone is a versatile scaffold that has a number of pharmacological properties. The successful development and ensuing approval of indanone-derived donepezil as a drug of choice for Alzheimer ' s disease attracted signi ficant scienti fic interest in this moiety. Indanones could act as small molecule chemical probes as they have strong af finity towards several critical enzymes associated with the pathophysiology of various neurological disorders. Inhibition of these enzymes elevates the levels of neuroprotective brain chemicals such as norepinephrine, serotonin and dopamine. Further, indanone derivatives are capable of modulating the activities of both monoamine oxidases (MAO-A and-B) and acetylcholinesterase (AChE), and thus could be useful in various neurodegenerative diseases. This review article presents a panoramic view of the research carried out on the indanone nucleus in the development of potential neuroprotective agents.

引用

页数：15

共 97 条

[1] Novel indanone derivatives as MAO B/H3R dual-targeting ligands for treatment of Parkinson's disease [J].

Affini, Anna ;

Hagenow, Stefanie ;

Zivkovic, Aleksandra ;

Marco-Contelles, Jose ;

Stark, Holger .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 148 :487-497

[2] The potential of anti-inflammatory drugs for the treatment of Alzheimer's disease [J].

Aisen, PS .

LANCET NEUROLOGY, 2002, 1 (05) :279-284

[3] Design, synthesis and evaluation of novel 5,6-dimethoxy-1-oxo-2,3-dihydro-1H-2-indenyl-3,4-substituted phenyl methanone analogues [J].

Ali, Mohamed Ashraf ;

Yar, Mohammad Shahar ;

Hasan, Mohamed Zaheen ;

Ahsan, Mohamed Jawed ;

Pandian, Suresh .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (17) :5075-5077

[4] A review on cholinesterase inhibitors for Alzheimer's disease [J].

Anand, Preet ;

Singh, Baldev .

ARCHIVES OF PHARMACAL RESEARCH, 2013, 36 (04) :375-399

[5] Risk factors for Alzheimer's disease [J].

Armstrong, Richard A. .

FOLIA NEUROPATHOLOGICA, 2019, 57 (02) :87-105

[6] An NMR Spectroscopic Method to Identify and Classify Thiol-Trapping Agents: Revival of Michael Acceptors for Drug Discovery? [J].

Avonto, Cristina ;

Taglialatela-Scafati, Orazio ;

Pollastro, Federica ;

Minassi, Alberto ;

Di Marzo, Vincenzo ;

De Petrocellis, Luciano ;

Appendino, Giovanni .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2011, 50 (02) :467-471

[7] Synthesis, in silico Studies and Pharmacological Evaluation of a New Series of Indanone Derivatives as Anti-Parkinsonian and Anti-Alzheimer's Agents [J].

Bansal, Ranju ;

Singh, Ranjit ;

Rana, Pratibha .

CURRENT COMPUTER-AIDED DRUG DESIGN, 2023, 19 (02) :94-107

[8] Neurodegenerative diseases and oxidative stress [J].

Barnham, KJ ;

Masters, CL ;

Bush, AI .

NATURE REVIEWS DRUG DISCOVERY, 2004, 3 (03) :205-214

[9] Exploring the structure-activity relationship of benzylidene-2,3-dihydro-1H-inden-1-one compared to benzofuran-3(2H)-one derivatives as inhibitors of tau amyloid fibers [J].

Boukherrouba, Emeline ;

Larosa, Camille ;

Nguyen, Kim-Anh ;

Caburet, Jeremy ;

Lunven, Laurent ;

Bonnet, Hugues ;

Fortune, Antoine ;

Boumendjel, Ahcene ;

Boucherle, Benjamin ;

Chierici, Sabine ;

Peuchmaur, Marine .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 231

[10] Comprehensive Review on Alzheimer's Disease: Causes and Treatment [J].

Breijyeh, Zeinab ;

Karaman, Rafik .

MOLECULES, 2020, 25 (24)

← 1 2 3 4 5 6 7 8 9 10 →