Epidemiological Insights into Autoimmune Bullous Diseases in China: A Comprehensive Analysis

被引:1
作者
Chen, Zihua [1 ]
Wang, Lanting [1 ]
Ma, Li [1 ]
Yang, Fanping [1 ]
Chen, Shengan [1 ]
Yang, Jin [1 ]
Gao, Haiqing [1 ]
Tang, Chang [1 ]
Zhao, Ying [1 ]
Zhang, Zhen [1 ]
Tang, Lin [1 ]
Xue, Haiyu [1 ]
Ying, Jian [1 ]
Xu, Yu [1 ]
Zhang, Wenhong [2 ]
Shao, Lingyun [2 ]
Liu, Hanqiu [3 ]
Luo, Xiaoqun [1 ]
机构
[1] Fudan Univ, Huashan Hosp, Res Ctr Allergy & Dis, Dept Allergy & Immunol,Dept Dermatol, 12 Middle Urumqi Rd, Shanghai 200040, Peoples R China
[2] Fudan Univ, Dept Infect Dis, Huashan Hosp, Shanghai, Peoples R China
[3] Fudan Univ, Dept Radiol, Huashan Hosp, Shanghai, Peoples R China
关键词
Autoimmune bullous disease; Pemphigus; Pemphigoid; Interstitial lung disease; Mortality; Triggers; Risk factors; Comorbidity; PEMPHIGUS; DERMATOSES; SPECTRUM;
D O I
10.1007/s44197-024-00277-7
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
ObjectiveThis study aims to conduct an extensive analysis of autoimmune bullous diseases, particularly pemphigus vulgaris and bullous pemphigoid, in Shanghai, China, from 2016 to 2023. It seeks to understand the demographic profiles, comorbidities, mortality rates, risk factors, and socioeconomic impacts associated with autoimmune bullous disease.MethodsA cross-sectional study design was employed, enrolling 1,072 patients. Diagnostic measures included clinical manifestations, histopathology, direct immunofluorescence, and serologic tests. The study also involved a detailed socioeconomic analysis and evaluation of occupational risks.ResultsThe findings highlight a significant occupational risk in industries requiring enhanced safety measures, with a notable prevalence of autoimmune bullous disease among workers in these sectors. A considerable portion of the patients were from low-income backgrounds with limited literacy, indicating the economic burden of autoimmune bullous disease. A key discovery of the study is the potential pathological link between autoimmune bullous disease and interstitial lung disease.ConclusionThis research, one of the first comprehensive studies on autoimmune bullous disease in China, underscores the need for targeted healthcare strategies and further investigation into autoimmune bullous disease, particularly its relationship with interstitial lung disease.
引用
收藏
页码:513 / 523
页数:11
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