Deciphering DNA Methylation in Gestational Diabetes Mellitus: Epigenetic Regulation and Potential Clinical Applications

被引：2
作者：
Li, Nan [1 ]
Liu, Huan-Yu [2 ,3 ]
Liu, Song-Mei [1 ,3 ]
机构：
[1] Wuhan Univ, Zhongnan Hosp, Dept Clin Lab, 169 Donghu Rd, Wuhan 430071, Hubei, Peoples R China
[2] Wuhan Univ, Zhongnan Hosp, Dept Obstet, 169 Donghu Rd, Wuhan 430071, Peoples R China
[3] Hubei Clin Res Ctr Prenatal Diag & Birth Hlth, 169 Donghu Rd, Wuhan 430071, Peoples R China
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 17期
基金：
中国国家自然科学基金;
关键词：
gestational diabetes mellitus; DNA methylation; epigenetics; EPIGENOME-WIDE ASSOCIATION; BETA-CELL DEATH; CORD BLOOD; GLUCOSE-INTOLERANCE; GENE-EXPRESSION; PREGNANT-WOMEN; EXPOSURE; METHYLOME; PLACENTA; BIRTH;
D O I：
10.3390/ijms25179361
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Gestational diabetes mellitus (GDM) represents a prevalent complication during pregnancy, exerting both short-term and long-term impacts on maternal and offspring health. This review offers a comprehensive outline of DNA methylation modifications observed in various maternal and offspring tissues affected by GDM, emphasizing the intricate interplay between DNA methylation dynamics, gene expression, and the pathogenesis of GDM. Furthermore, it explores the influence of environmental pollutants, maternal nutritional supplementation, and prenatal gut microbiota on GDM development through alterations in DNA methylation profiles. Additionally, this review summarizes recent advancements in DNA methylation-based diagnostics and predictive models in early GDM detection and risk assessment for subsequent type 2 diabetes. These insights contribute significantly to our understanding of the epigenetic mechanisms underlying GDM development, thereby enhancing maternal and fetal health outcomes and advocating further efforts in this field.
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页数：21
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