Bridging the gap: a translational perspective in spinal cord injury

被引:0
|
作者
Hassan, Omar Imad [1 ,2 ]
Takamiya, Soichiro [1 ]
Asgarihafshejani, Azam [1 ]
Fehlings, Michael G. [1 ,2 ,3 ,4 ]
机构
[1] Univ Hlth Network, Krembil Brain Inst, Div Genet & Dev, Toronto, ON, Canada
[2] Univ Toronto, Inst Med Sci, Toronto, ON, Canada
[3] Univ Hlth Network, Toronto Western Hosp, Krembil Neurosci Ctr, Div Neurosurg, Toronto, ON, Canada
[4] Univ Toronto, Dept Surg, Div Neurosurg & Spine Program, Toronto, ON, Canada
关键词
spinal cord injury; neuroregeneration; animal models; clinical trials; pathophysiology; TRANSCRANIAL MAGNETIC STIMULATION; PLURIPOTENT STEM-CELLS; PROMOTES FUNCTIONAL RECOVERY; CLINICAL-PRACTICE GUIDELINE; MOTOR CORTEX; CHRONIC PAIN; BLOOD-FLOW; ICCP PANEL; DECOMPRESSIVE SURGERY; AXONAL REGENERATION;
D O I
10.3389/ebm.2024.10266
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Traumatic spinal cord injury (SCI) is a devastating and complex condition to treat with no curative options. In the past few decades, rapid advancements in our understanding of SCI pathophysiology as well as the mergence of new treatments has created more optimism. Focusing on clinical translation, this paper provides a comprehensive overview of SCI through its epidemiology, pathophysiology, currently employed management strategies, and emerging therapeutic approaches. Additionally, it emphasizes the importance of addressing the heavy quality of life (QoL) challenges faced by SCI patients and their desires, providing a basis to tailor patient-centric forms of care. Furthermore, this paper discusses the frequently encountered barriers in translation from preclinical models to clinical settings. It also seeks to summarize significant completed and ongoing SCI clinical trials focused on neuroprotective and neuroregenerative strategies. While developing a cohesive regenerative treatment strategy remains challenging, even modest improvements in sensory and motor function can offer meaningful benefits and motivation for patients coping with this highly debilitating condition.
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页数:25
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