Autophagy: Are Amino Acid Signals Dependent on the mTORC1 Pathway or Independent?

被引:0
作者
Jin, Chenglong [1 ,2 ,3 ,4 ]
Zhu, Min [5 ]
Ye, Jinling [1 ,2 ,3 ,4 ]
Song, Zhiwen [5 ]
Zheng, Chuntian [1 ,2 ,3 ,4 ]
Chen, Wei [1 ,2 ,3 ,4 ]
机构
[1] State Key Lab Swine & Poultry Breeding Ind, Guangzhou 510640, Peoples R China
[2] Guangdong Acad Agr Sci, Inst Anim Sci, Guangzhou 510640, Peoples R China
[3] Minist Agr & Rural Affairs, Key Lab Anim Nutr & Feed Sci South China, Guangzhou 510640, Peoples R China
[4] Guangdong Prov Key Lab Anim Breeding & Nutr, Guangzhou 510640, Peoples R China
[5] Guizhou Univ, Key Lab Anim Genet Breeding & Reprod Plateau Mt Re, Minist Educ, Coll Anim Sci, Guiyang 550025, Peoples R China
基金
中国国家自然科学基金;
关键词
amino acid; autophagy; molecular mechanism; mTORC1; SKELETAL-MUSCLE; PROTEIN-DEGRADATION; LYSINE; LEUCINE; COMPLEX; DEPRIVATION; MACROAUTOPHAGY; PROTEOLYSIS; APOPTOSIS; BECLIN-1;
D O I
10.3390/cimb46080519
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Autophagy is a kind of "self-eating" phenomenon that is ubiquitous in eukaryotic cells. It mainly manifests in the damaged proteins or organelles in the cell being wrapped and transported by the autophagosome to the lysosome for degradation. Many factors cause autophagy in cells, and the mechanism of nutrient-deficiency-induced autophagy has been a research focus. It has been reported that amino-acid-deficiency-induced cellular autophagy is mainly mediated through the mammalian rapamycin target protein complex 1 (mTORC1) signaling pathway. In addition, some researchers also found that non-mTORC1 signaling pathways also regulate autophagy, and the mechanism of autophagy occurrence induced by the deficiency of different amino acids is not precisely the same. Therefore, this review aims to summarize the process of various amino acids regulating cell autophagy and provide a narrative review on the molecular mechanism of amino acids regulating autophagy.
引用
收藏
页码:8780 / 8793
页数:14
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