Antioxidant, Anti-Inflammatory, Anti-Diabetic, and Pro-Osteogenic Activities of Polyphenols for the Treatment of Two Different Chronic Diseases: Type 2 Diabetes Mellitus and Osteoporosis

被引：23

作者：

Scarpa, Emanuele-Salvatore ^{[1
]}

Antonelli, Antonella ^{[2
]}

Balercia, Giancarlo ^{[3
]}

Sabatelli, Sofia ^{[4
]}

Maggi, Filippo ^{[5
]}

Caprioli, Giovanni ^{[5
]}

Giacchetti, Gilberta ^{[4
]}

Micucci, Matteo ^{[2
]}

机构：

[1] Mivell Srls, R&D Dept, I-61032 Fano, Italy

[2] Univ Urbino Carlo Bo, Dept Biomol Sci, I-61029 Urbino, Italy

[3] Univ Politecn Marche, Dept Clin & Mol Sci, Div Endocrinol, I-60126 Ancona, Italy

[4] Univ Politecn Marche, Dept Clin & Mol Sci, Clin Endocrinol & Metab Dis, I-60126 Ancona, Italy

[5] Univ Camerino, Sch Pharm, Chem Interdisciplinary Project CHIP Res Ctr, I-62032 Camerino, Italy

来源：

BIOMOLECULES | 2024年 / 14卷 / 07期

关键词：

polyphenols; type 2 diabetes mellitus; osteoporosis; anti-diabetic; pro-osteogenic; antioxidant; anti-inflammatory; HEPATITIS-C VIRUS; MORPHOGENETIC PROTEIN-2 EXPRESSION; OVARIECTOMY-INDUCED OSTEOPOROSIS; ALPHA-GLUCOSIDASE INHIBITION; BONE LOSS; IN-VIVO; OXIDATIVE STRESS; KAPPA-B; OSTEOCLAST DIFFERENTIATION; POSTMENOPAUSAL WOMEN;

D O I：

10.3390/biom14070836

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Polyphenols are natural bioactives occurring in medicinal and aromatic plants and food and beverages of plant origin. Compared with conventional therapies, plant-derived phytochemicals are more affordable and accessible and have no toxic side effects. Thus, pharmaceutical research is increasingly inclined to discover and study new and innovative natural molecules for the treatment of several chronic human diseases, like type 2 diabetes mellitus (T2DM) and osteoporosis. These pathological conditions are characterized by a chronic inflammatory state and persistent oxidative stress, which are interconnected and lead to the development and worsening of these two health disorders. Oral nano delivery strategies have been used to improve the bioavailability of polyphenols and to allow these natural molecules to exert their antioxidant, anti-inflammatory, anti-diabetic, and pro-osteogenic biological activities in in vivo experimental models and in patients. Polyphenols are commonly used in the formulations of nutraceuticals, which can counteract the detrimental effects of T2DM and osteoporosis pathologies. This review describes the polyphenols that can exert protective effects against T2DM and osteoporosis through the modulation of specific molecular markers and pathways. These bioactives could be used as adjuvants, in combination with synthetic drugs, in the future to develop innovative therapeutic strategies for the treatment of T2DM and osteoporosis.

引用

页数：30

共 234 条

[1] Rutin Isolated from Chrozophora tinctoria Enhances Bone Cell Proliferation and Ossification Markers [J].