Potential of mesoporous silica nanoparticles for the delivery of anticancer bioactive compounds

被引：2

作者：

Diaz-Cervantes, Erik ^{[2
]}

Navarro-Garcia, Nayeli Edith ^{[1
]}

Rodriguez-Gonzalez, Vicente ^{[1
]}

机构：

[1] Inst Potosino Invest Cient & Tecnol, Div Mat Avanzados, Camino Presa San Jose 2055,Lomas 4Ta, San Luis Potosi 78216, Mexico

[2] Univ Guanajuato, Ctr Interdisciplinario Noreste CINUG, Dept Alimentos, Tierra Blanca 37975, Guanajuato, Mexico

来源：

MATERIALS LETTERS | 2024年 / 373卷

关键词：

Mesoporous SiO 2; Anticancer delivery; In-silico; Biomaterials; Carvacrol; DRUG-DELIVERY;

D O I：

10.1016/j.matlet.2024.137144

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

The potential for dosing anticancer target molecules of silica nanoparticles with ordered mesoporosity (SiMONPs), 28 nm in diameter and surface area of 706 m2/g, was evaluated by the loading and release of carvacrol, chloroquine, and rhodamine-B. The ligand-protein interaction (BRAF oncogene) was determined by docking. The fine structure of the SiMONPs with nanometric porosity allowed a slow and progressive release according to the passive diffusion mechanism. The most favorable anticancer interaction was displayed by carvacrol with a ligand efficiency value of -6.7 kcal/mol. At the same time, chloroquine and rhodamine-B had values of -5.0 kcal/mol and -3.4 kcal/mol, severally. The target displayed a "preference" to interact first with the SiMONPs rather than with carvacrol. The material could be dosed at 0.0009 mg/h for a week under PBS medium conditions, so the material resulted suitable for dosing and controlling the growth of skin cancer cells.

引用

页数：4