Breakthrough SARS-CoV-2 infection in fully vaccinated patients with systemic lupus erythematosus: results from the COVID-19 Vaccination in Autoimmune Disease (COVAD) study

被引：0

作者：

Palazzo, Leonardo ^{[1
,2
]}

Lindblom, Julius ^{[1
,2
]}

Olsson, Emelie Kihlgren ^{[1
,2
]}

Nikiphorou, Elena ^{[3
,4
]}

Wincup, Chris ^{[5
,6
]}

Saha, Sreoshy ^{[7
]}

Shaharir, Syahrul Sazliyana ^{[8
]}

Katchamart, Wanruchada ^{[9
]}

Goo, Phonpen Akarawatcharangura ^{[10
]}

Traboco, Lisa ^{[11
]}

Chen, Yi-Ming ^{[12
,13
]}

Lilleker, James B. ^{[14
,15
]}

Nune, Arvind ^{[16
]}

Pauling, John D. ^{[17
,18
]}

Agarwal, Vishwesh ^{[19
]}

Dzifa, Dey ^{[20
]}

Gutierrez, Carlos Enrique Toro ^{[21
]}

Caballero-Uribe, Carlo V. ^{[22
]}

Chinoy, Hector ^{[14
,23
,24
]}

Agarwak, Vikas ^{[25
]}

Gupta, Latika ^{[14
,26
]}

Parodis, Ioannis ^{[1
,2
,27
]}

机构：

[1] Karolinska Inst, Dept Med Solna, Div Rheumatol, Stockholm, Sweden

[2] Karolinska Univ Hosp, Stockholm, Sweden

[3] Kings Coll London, Ctr Rheumat Dis, London, England

[4] Kings Coll Hosp London, Rheumatol Dept, London, England

[5] UCL, Rayne Inst, Dept Rheumatol, Div Med, London, England

[6] UCLH, Ctr Adolescent Rheumatol Versus Arthrit UCL, GOSH, London, England

[7] Mymensingh Med Coll, Mymensingh, Bangladesh

[8] Univ Kebangsaan Malaysia, Fac Med, Kuala Lumpur, Malaysia

[9] Mahidol Univ, Fac Med Siriraj Hosp, Dept Med, Div Rheumatol, Bangkok, Thailand

[10] Queen Savang Vadhana Mem Hosp, Dept Med, Chon Buri, Thailand

[11] St Lukes Med Ctr Global City, Dept Med, Sect Rheumatol, Taguig, Philippines

[12] Taichung Vet Gen Hosp, Dept Internal Med, Div Allergy Immunol & Rheumatol, Taichung, Taiwan

[13] Taichung Vet Gen Hosp, Dept Med Res, Taichung, Taiwan

[14] Univ Manchester, Ctr Musculoskeletal Res, Manchester Acad Hlth Sci Ctr, Fac Biol,Div Musculoskeletal & Dermatol Sci,Sch B, Manchester, England

[15] Salford Royal NHS Fdn Trust, Manchester Ctr Clin Neurosci, Salford, England

[16] Southport & Ormskirk Hosp NHS Trust, Southport, England

[17] Bristol Med Sch Translat Hlth Sci, Hlth Sci, Bristol, England

[18] North Bristol NHS Trust, Dept Rheumatol, Bristol, England

[19] Mahatma Gandhi Mission Med Coll, Navi Mumbai, Maharashtra, India

[20] Univ Ghana Med Sch, Coll Hlth Sci, Dept Med & Therapeut, Rheumatol Unit, Accra, Ghana

[21] Pontificia Univ Javeriana Cali, Reference Ctr Osteoporosis, Rheumatol & Dermatol, Cali, Colombia

[22] Hosp Univ Norte, Dept Med, Barranquilla, Atlantico, Colombia

[23] Univ Manchester, Manchester Univ NHS Fdn Trust, Natl Inst Hlth Res Manchester Biomed Res Ctr, Manchester, England

[24] Salford Royal Hosp, Northern Care Alliance NHS Fdn Trust, Dept Rheumatol, Salford, England

[25] Sanjay Gandhi Postgrad Inst Med Sci, Dept Clin Immunol & Rheumatol, Lucknow, India

[26] Royal Wolverhampton Hosp NHS Trust, Dept Rheumatol, Wolverhampton, England

[27] Orebro Univ, Fac Med & Hlth, Dept Rheumatol, Orebro, Sweden

来源：

RHEUMATOLOGY INTERNATIONAL | 2024年

关键词：

COVID-19; Vaccination; Breakthrough infection; Systemic lupus erythematosus; Rheumatology; Autoimmune disease; Survey; IMPACT;

D O I：

10.1007/s00296-024-05682-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective To determine the occurrence of breakthrough COVID-19 infections (BIs) in patients with systemic lupus erythematosus (SLE) compared with patients with other rheumatic autoimmune diseases (rAIDs), patients with non-rheumatic autoimmune diseases (nrAIDs), and healthy controls (HCs). Methods The study was based on data from 7035 fully vaccinated respondents to the online COVAD questionnaire with SLE (N = 852), rAIDs (N = 3098), or nrAIDs (N = 414), and HCs (N = 2671). BI was defined as COVID-19 infection occurring in individuals vaccinated with >= 2 doses (or 1 dose of J&J) >= 14 days after vaccination and not after 6 months since the last vaccine dose. Data were analysed using linear and logistic regression models. Results A total of 91/852 (10.7%) SLE patients reported at least one BI. The frequency of BIs in SLE patients was comparable to that among HCs (277/2671; p = 0.847) and patients with nrAID (39/414; p = 0.552) but higher than that among patients with other rAIDs (235/3098; p = 0.005). No demographic factors or treatments were associated with BIs in SLE patients (p >= 0.05 for all). Joint pain was more frequent in SLE patients than in HCs (odds ratio [OR]: 3.38; 95% confidence interval [CI]: 1.89-6.04; p < 0.001) or nrAID patients (OR: 2.44; 95% CI: 1.04-5.75; p = 0.041). Patient with SLE did not report a higher frequency of hospitalisation or need for advanced treatment for COVID-19 infection compared with disease controls and HCs, respectively. Conclusion COVID-19 vaccination conferred similar protection against COVID-19 infection in terms of frequency and severity in patients with SLE to that reported by healthy individuals.

引用

页码：1923 / 1933

页数：11

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