This study investigates the interplay between telework frequency, communication media, and knowledge sharing during telework brought about by COVID-19 in the United States. Analyzing data from 614 participants with prior telework experience, the research unveiled nuanced associations between these variables. While higher telework frequency positively correlated with increased phone calls, chat, and virtual meetings, face-to-face interactions and email frequency remained unaffected. Furthermore, phone calls, chat, and virtual meetings exhibited positive links with knowledge sharing, confirming a mediation effect of these 3 communication media between telework frequency and knowledge sharing. This emphasizes the pivotal role of technology-based synchronous communication tools in mediating knowledge exchange within remote work contexts. The findings underscore the need for organizations to foster dynamic communication strategies, prioritizing interactive channels to optimize collaboration and information dissemination in remote work environments. Understanding these dynamics presents crucial insights for shaping effective communication frameworks and maximizing knowledge sharing in contemporary remote work scenarios.