Novel Tubeimoside I liposomal drug delivery system in combination with gemcitabine for the treatment of pancreatic cancer

被引：0
作者：
Li, Shuhui [1 ]
Liu, Yuansheng [2 ]
Sui, Xiaojun [3 ,4 ]
Zhuo, Yuzhen [3 ]
Siqi, He [4 ]
Sijia, Zhang [4 ]
Hui, Zhang [3 ]
Dihua, Li [3 ]
Dapeng, Zhang [3 ]
Lei, Yang [3 ]
机构：
[1] Tianjin Univ Tradit Chinese Med, Sch Tradit Chinese Med, Tianjin 301617, Peoples R China
[2] Tianjin Union Med Ctr, Dept Colorectal Surg, Tianjin 300000, Peoples R China
[3] Tianjin Med Univ, Tianjin Nankai Hosp, Tianjin Key Lab Organ Injury & ITCWM Repair Associ, Tianjin 300100, Peoples R China
[4] Tianjin Med Univ, Grad Sch, Tianjin 300270, Peoples R China
来源：
NANOMEDICINE | 2024年 / 19卷 / 24期
关键词：
F18-FDG micro-PET/CT imaging; gemcitabine; liposomes; pancreatic cancer; tubular alfalfa glycosides I; tumor microenvironment; CHOLESTEROL; PACLITAXEL; SAPONINS; KINETICS; RELEASE;
D O I：
10.1080/17435889.2024.2382076
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Aim: To evaluate the anti-pancreatic cancer effect of novel Tubeimoside I multifunctional liposomes combined with gemcitabine. Methods: Liposomes were prepared through the thin film hydration method, with evaluations conducted on parameters including encapsulation efficiency (EE%), particle size, polydispersity index (PDI), zeta potential (ZP), storage stability, and release over a 7-day period. The cellular uptake rate, therapeutic efficacy in vitro and in vivo and the role of immune microenvironment modulation were evaluated. Results: The novel Tubeimoside I multifunctional liposomal exhibited good stability, significant anti-cancer activity, and immune microenvironment remodeling effects. Furthermore, it showed a safety profile. Conclusion: This study underscores the potential of Novel Tubeimoside I multifunctional liposomal as a promising treatment option for pancreatic cancer.
引用
收藏
页码：1977 / 1993
页数：17
相关论文
共 49 条
[1]   A multifunctional lipid nanoparticle for co-delivery of paclitaxel and curcumin for targeted delivery and enhanced cytotoxicity in multidrug resistant breast cancer cells [J].
Baek, Jong-Suep ;
Cho, Cheong-Weon .
ONCOTARGET, 2017, 8 (18) :30369-30382
[2]   Role of taxanes in pancreatic cancer [J].
Belli, Carmen ;
Cereda, Stefano ;
Reni, Michele .
WORLD JOURNAL OF GASTROENTEROLOGY, 2012, 18 (33) :4457-4465
[3]   Real world evidence on gemcitabine and nab-paclitaxel combination chemotherapy in advanced pancreatic cancer [J].
Blomstrand, Hakon ;
Scheibling, Ursula ;
Bratthall, Charlotte ;
Green, Henrik ;
Elander, Nils O. .
BMC CANCER, 2019, 19 (1)
[4]   Nanomedicine for Imaging and Therapy of Pancreatic Adenocarcinoma [J].
Brachi, Giulia ;
Bussolino, Federico ;
Ciardelli, Gianluca ;
Mattu, Clara .
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2019, 7
[5]   All-in-One Nanomedicine: Multifunctional Single-Component Nanoparticles for Cancer Theranostics [J].
Cai, Yu ;
Chen, Xiaoyi ;
Si, Jingxing ;
Mou, Xiaozhou ;
Dong, Xiaochen .
SMALL, 2021, 17 (52)
[6]   Peptide-22 and Cyclic RGD Functionalized Liposomes for Glioma Targeting Drug Delivery Overcoming BBB and BBTB [J].
Chen, Cuitian ;
Duan, Ziqing ;
Yuan, Yan ;
Li, Ruixiang ;
Pang, Liang ;
Liang, Jianming ;
Xu, Xinchun ;
Wang, Jianxin .
ACS APPLIED MATERIALS & INTERFACES, 2017, 9 (07) :5864-5873
[7]   Tubeimoside I Inhibits Cell Proliferation and Induces a Partly Disrupted and Cytoprotective Autophagy Through Rapidly Hyperactivation of MEK1/2-ERK1/2 Cascade via Promoting PTP1B in Melanoma [J].
Du, Juan ;
Dong, Zhen ;
Tan, Li ;
Tan, Mengqin ;
Zhang, Fang ;
Zhang, Kui ;
Pan, Guangzhao ;
Li, Chongyang ;
Shi, Shaomin ;
Zhang, Yanli ;
Liu, Yaling ;
Cui, Hongjuan .
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2020, 8
[8]   Microenvironmental regulation in tumor progression: Interactions between cancer-associated fibroblasts and immune cells [J].
Gao, Dandan ;
Fang, Liguang ;
Liu, Cun ;
Yang, Mengrui ;
Yu, Xiaoyun ;
Wang, Longyun ;
Zhang, Wenfeng ;
Sun, Changgang ;
Zhuang, Jing .
BIOMEDICINE & PHARMACOTHERAPY, 2023, 167
[9]   Long-term therapeutic silencing of miR-33 increases circulating triglyceride levels and hepatic lipid accumulation in mice [J].
Goedeke, Leigh ;
Salerno, Alessandro ;
Ramirez, Cristina M. ;
Guo, Liang ;
Allen, Ryan M. ;
Yin, Xiaoke ;
Langley, Sarah R. ;
Esau, Christine ;
Wanschel, Amarylis ;
Fisher, Edward A. ;
Suarez, Yajaira ;
Baldan, Angel ;
Mayr, Manuel ;
Fernandez-Hernando, Carlos .
EMBO MOLECULAR MEDICINE, 2014, 6 (09) :1133-1141
[10]   Tubeimoside 1 Acts as a Chemotherapeutic Synergist via Stimulating Macropinocytosis [J].
Gong, Xianling ;
Sun, Ruibo ;
Gao, Zhuowei ;
Han, Weili ;
Liu, Yawei ;
Zhao, Liang ;
Jing, Linlin ;
Yao, Xueqing ;
Sun, Xuegang .
FRONTIERS IN PHARMACOLOGY, 2018, 9
12345