Effects of Pea (Pisum sativum) Prebiotics on Intestinal Iron-Related Proteins and Microbial Populations In Vivo (Gallus gallus)

被引:1
作者
Armah, Abigail [1 ]
Jackson, Cydney [1 ]
Kolba, Nikolai [1 ]
Gracey, Peter R. [1 ]
Shukla, Viral [1 ]
Padilla-Zakour, Olga I. [1 ]
Warkentin, Tom [2 ]
Tako, Elad [1 ]
机构
[1] Cornell Univ, Dept Food Sci, Ithaca, NY 14850 USA
[2] Univ Saskatchewan, Crop Dev Ctr, Dept Plant Sci, 51 Campus Dr, Saskatoon, SK S7N 5A8, Canada
关键词
iron bioavailability; pea seed coat; microbial population; brush boarder membrane; prebiotics; Gallus gallus; gut microbiome; HUMAN-NUTRITION; DIETARY FIBER; SEED COATS; BIOAVAILABILITY; ABSORPTION; POLYPHENOLS; STARCH; PULSES; ANEMIA; IMPACT;
D O I
10.3390/nu16121856
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Iron deficiency remains a public health challenge globally. Prebiotics have the potential to improve iron bioavailability by modulating intestinal bacterial population, increasing SCFA production, and stimulating expression of brush border membrane (BBM) iron transport proteins among iron-deficient populations. This study intended to investigate the potential effects of soluble extracts from the cotyledon and seed coat of three pea (Pisum sativum) varieties (CDC Striker, CDC Dakota, and CDC Meadow) on the expression of BBM iron-related proteins (DCYTB and DMT1) and populations of beneficial intestinal bacteria in vivo using the Gallus gallus model by oral gavage (one day old chicks) with 1 mL of 50 mg/mL pea soluble extract solutions. The seed coat treatment groups increased the relative abundance of Bifidobacterium compared to the cotyledon treatment groups, with CDC Dakota seed coat (dark brown pigmented) recording the highest relative abundance of Bifidobacterium. In contrast, CDC Striker Cotyledon (dark-green-pigmented) significantly increased the relative abundance of Lactobacillus (p < 0.05). Subsequently, the two dark-pigmented treatment groups (CDC Striker Cotyledon and CDC Dakota seed coats) recorded the highest expression of DCYTB. Our study suggests that soluble extracts from the pea seed coat and dark-pigmented pea cotyledon may improve iron bioavailability by affecting intestinal bacterial populations.
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页数:16
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