Chronic myelomonocytic leukemia with NPM1 mutation or acute myeloid leukemia?

被引：2

作者：

Castano-Diez, Sandra ^{[1
,2
,3
]}

Alamo, Jose Ramon ^{[4
]}

Lopez-Guerra, Monica ^{[2
,4
,5
]}

Gomez-Hernando, Marta

Zugasti, Ines ^{[1
]}

Jimenez-Vicente, Carlos ^{[1
]}

Guijarro, Francesca ^{[2
,3
,4
]}

Lopez-Oreja, Irene ^{[4
]}

Esteban, Daniel

Charry, Paola

Torrecillas, Victor ^{[3
]}

Mont-de Torres, Lucia ^{[3
]}

Cortes-Bullich, Albert ^{[1
]}

Bataller, Alex ^{[1
,2
,3
,6
]}

Guardia, Ares ^{[1
]}

Munarriz, Daniel ^{[1
]}

Carcelero, Esther ^{[7
]}

Riu, Gisela ^{[7
]}

Triguero, Ana ^{[1
]}

Tovar, Natalia ^{[1
]}

Vela, Dolors ^{[8
]}

Bea, Silvia ^{[2
,4
,5
]}

Costa, Dolors ^{[2
,4
,5
]}

Colomer, Dolors ^{[2
,4
,5
]}

Rozman, Maria ^{[2
,4
]}

Esteve, Jordi ^{[1
,2
,3
,6
]}

Diaz-Beya, Marina ^{[1
,2
,6
]}

机构：

[1] Hosp Clin Barcelona, Hematol Dept, Barcelona, Spain

[2] Inst Invest Biomed August Pi i Sunyer IDIBAPS, Barcelona, Spain

[3] Univ Barcelona, Barcelona, Spain

[4] Hosp Clin Barcelona, Pathol Dept, Hematopathol Sect, Barcelona, Spain

[5] Ctr Invest Biomed Red Canc CIBERONC, Madrid, Spain

[6] Josep Carreras Leukemia Res Inst, Badalona, Spain

[7] Hosp Clin Barcelona, Pharm Serv, Barcelona, Spain

[8] Hosp Gen Granollers, Hematol Dept, Granollers, Spain

来源：

ONCOLOGIST | 2024年 / 30卷 / 02期

关键词：

chronic myelomonocytic leukemia; NPM1; acute myeloid leukemia; CMML; NPM1mut CMML; AML; CMML treatment; FLT3; MUTATIONS; NUCLEOPHOSMIN; DNMT3A;

D O I：

10.1093/oncolo/oyae246

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The 2022 WHO revision and the ICC classification have recently modified the diagnostic criteria for chronic myelomonocytic leukemia (CMML) and acute myeloid leukemia. However, there is no consensus on whether CMML with NPM1 mutation (NPM1mut) should be diagnosed as AML. Nowadays, it is a subject of discussion because of its diagnostic and therapeutic implications. Therefore, we describe a case of a patient diagnosed with CMML NPM1mut and briefly review the literature to highlight the uncertainty about how to classify a CMML with NPM1 mutation. We emphasize the importance of a comprehensive molecular study, which is crucial to optimize the individualized treatment of patients, enabling them to access targeted therapies. This brief communication describes the case of a patient diagnosed with chronic myelomonocytic leukemia with NPM1 mutation and briefly review the literature to highlight the uncertainty about how to classify this condition.

引用

页数：6

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