Microglial activation and polarization in type 2 diabetes-related cognitive impairment: A focused review of pathogenesis

被引：6
作者：
Tian, Yue [1 ]
Jing, Guangchan [1 ]
Ma, Mei [1 ]
Yin, Ruiying [1 ]
Zhang, Mengren [1 ]
机构：
[1] Peking Union Med Coll & Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Tradit Chinese Med, 1 Shuaifuyuan, Beijing 100730, Peoples R China
来源：
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 2024年 / 165卷
关键词：
Microglia; Type 2 diabetes-related cognitive impairment; Inflammatory responses; Neuronal apoptosis; Amyloid-(3; Tau protein; Clinical translation; HIPPOCAMPAL INSULIN-RESISTANCE; ALZHEIMERS-DISEASE; NEURONAL DEATH; M2; MICROGLIA; NEUROINFLAMMATION; MODEL; DYSFUNCTION; MEMORY; HYPERINSULINEMIA; METAANALYSIS;
D O I：
10.1016/j.neubiorev.2024.105848
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Microglia, as immune cells in the central nervous system, are closely related to cognitive impairment associated with type 2 diabetes (T2D). Preliminary explorations have investigated the relationship between T2D-related cognitive impairment and the activation and polarization of microglia. This review summarizes the potential mechanisms of microglial activation and polarization in the context of T2D. It discusses central inflammatory responses, neuronal apoptosis, amyloid-(3 deposition, and abnormal phosphorylation of Tau protein mediated by microglial activation and polarization, exploring the connections between microglial activation and polarization and T2D-related cognitive impairment from multiple perspectives. Additionally, this review provides references for future treatment targeting microglia in T2D-related cognitive impairment and for clinical translation.
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页数：13
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