Diastolic dysfunction in hypertension: a comprehensive review of pathophysiology, diagnosis, and treatment

Diastolic dysfunction refers to impaired relaxation or filling of the ventricles during the diastolic phase of the cardiac cycle. Left ventricular diastolic dysfunction (LVDD) is common in hypertensive individuals and is associated with increased morbidity and mortality. LVDD serves as a critical precursor to heart failure, particularly heart failure with preserved ejection fraction. The pathophysiology of LVDD in hypertension is complex, involving alterations in cardiac structure and function, neurohormonal activation, and vascular stiffness. While the diagnosis of LVDD relies primarily on echocardiography, management remains challenging due to a lack of specific treatment guidelines for LVDD. This review offers an overview of the pathophysiological mechanisms underlying LVDD in hypertension, diagnostic methods, clinical manifestations, strategies for managing LVDD, and prospects for future research. Graphical Abstract Illustration of the complex interplay between hypertension, cardiac remodelling (LVH), LVDD, and HFpEF, modified with permission from Nadruz W., Shah A.M., Solomon S.D. Medical Clinics of North America, 2017, Copyright Elsevier (1).