Frontiers in CAR-T cell therapy for autoimmune diseases

被引：20

作者：

Li, Yan-Ruide ^{[1
]}

Lyu, Zibai ^{[1
]}

Chen, Yuning ^{[1
]}

Fang, Ying ^{[1
]}

Yang, Lili ^{[1
,2
,3
,4
]}

机构：

[1] Univ Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Mol Biol Inst, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, Eli & Edythe Broad Ctr Regenerat Med & Stem Cell R, Los Angeles, CA 90095 USA

[4] Univ Calif Los Angeles, David Geffen Sch Med, Jonsson Comprehens Canc Ctr, Los Angeles, CA 90095 USA

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2024年 / 45卷 / 09期

关键词：

RHEUMATOID-ARTHRITIS PATIENTS; B-CELLS; LEUKEMIA; RITUXIMAB; BELIMUMAB; EFFICACY; ANTIBODY; COLITIS; MODELS; FUTURE;

D O I：

10.1016/j.tips.2024.07.005

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Chimeric antigen receptor (CAR)-engineered T (CAR-T) cell therapy has demonstrated significant success in treating cancers. The potential of CAR-T cells is now being explored in the context of autoimmune diseases. Recent clinical trials have shown sustained and profound elimination of autoreactive B cells by CAR-T cells, leading to promising autoimmune disease control with minimal safety concerns. These encouraging results have inspired further investigation into CAR-T cell applications for a broader range of autoimmune diseases and the development of advanced cell products with improved efficacy and safety. In this review, we discuss the mechanisms by which CAR-T cells target autoimmune conditions, summarize current preclinical models, and highlight ongoing clinical trials, including CAR-T therapy design, clinical outcomes, and challenges. Additionally, we discuss the limitations and future directions of CAR-T therapy in the treatment of autoimmune diseases.

引用

页码：839 / 857

页数：19

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