Dysregulated microRNAs in type 2 diabetes and breast cancer: Potential associated molecular mechanisms

被引：2

作者：

Improta-Caria, Alex Cleber ^{[1
]}

Ferrari, Filipe ^{[2
]}

Gomes, Joao Lucas Penteado ^{[1
]}

Villalta, Paloma Brasilio ^{[3
]}

Soci, Ursula Paula Reno ^{[1
]}

Stein, Ricardo ^{[2
]}

Oliveira, Edilamar M. ^{[1
,4
,5
]}

机构：

[1] Univ Sao Paulo, Phys Educ & Sport Sch, Lab Biochem & Mol Biol Exercise, 65 Vila Univ, BR-05508030 Sao Paulo, Brazil

[2] Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Grad Program Cardiol & Cardiovasc Sci, BR-90035003 Porto Alegre, Brazil

[3] Univ Campinas UNICAMP, Sch Appl Sci, Lab Metab Disorders Labdime, BR-13484350 Campinas, Brazil

[4] Univ S Florida, USF Hlth Heart Inst, Morsani Coll Med, Ctr Regenerat Med,Dept Internal Med, Tampa, FL 33602 USA

[5] Univ S Florida, USF Hlth Heart Inst, Morsani Coll Med, Ctr Regenerat Med,Dept Mol Pharmacol & Physiol, Tampa, FL 33602 USA

来源：

WORLD JOURNAL OF DIABETES | 2024年 / 15卷 / 06期

关键词：

Type; 2; diabetes; Breast cancer; MicroRNAs; Molecular mechanisms; POSITIVE PREDICTIVE-VALUE; CIRCULATING MICRORNAS; CELL DYSFUNCTION; RISK-FACTORS; EXPRESSION; PATHOPHYSIOLOGY; MICROCALCIFICATIONS; GLUCOTOXICITY; HALLMARKS; MELLITUS;

D O I：

10.4239/wjd.v15.i6.1187

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Type 2 diabetes (T2D) is a multifaceted and heterogeneous syndrome associated with complications such as hypertension, coronary artery disease, and notably, breast cancer (BC). The connection between T2D and BC is established through processes that involve insulin resistance, inflammation and other factors. Despite this comprehension the specific cellular and molecular mechanisms linking T2D to BC, especially through microRNAs (miRNAs), remain elusive. miRNAs are regulators of gene expression at the post-transcriptional level and have the function of regulating target genes by modulating various signaling pathways and biological processes. However, the signaling pathways and biological processes regulated by miRNAs that are associated with T2D and BC have not yet been elucidated. This review aims to identify dysregulated miRNAs in both T2D and BC, exploring potential signaling pathways and biological processes that collectively contribute to the development of BC.

引用

页数：13

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