Revolutionizing Donor Heart Procurement: Innovations and Future Directions for Enhanced Transplantation Outcomes

被引:0
作者
Leon, Marc [1 ]
机构
[1] Stanford Univ, Sch Med, Dept Cardiothorac Surg, 300 Pasteur Dr,Falk CVRB, Stanford, CA 94305 USA
关键词
heart transplantation; donor heart procurement; donation after circulatory death; extended-criteria donors; artificial intelligence; GRAFT DYSFUNCTION; COLD-STORAGE; ORGAN DONORS; IMPACT; DEATH; DONATION; SURVIVAL; EXPERIENCE; PRESERVATION; AGE;
D O I
10.3390/jcdd11080235
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Heart failure persists as a critical public health challenge, with heart transplantation esteemed as the optimal treatment for patients with end-stage heart failure. However, the limited availability of donor hearts presents a major obstacle to meeting patient needs. In recent years, the most groundbreaking progress in heart transplantation has been in donor heart procurement, significantly expanding the donor pool and enhancing clinical outcomes. This review comprehensively examines these advancements, including the resurgence of heart donation after circulatory death and innovative recovery and evaluation technologies such as normothermic machine perfusion and thoraco-abdominal normothermic regional perfusion. Additionally, novel preservation methods, including controlled hypothermic preservation and hypothermic oxygenated perfusion, are evaluated. The review also explores the use of extended-criteria donors, post-cardiopulmonary resuscitation donors, and high-risk donors, all contributing to increased donor availability without compromising outcomes. Future directions, such as xenotransplantation, biomarkers, and artificial intelligence in donor heart evaluation and procurement, are discussed. These innovations promise to address current limitations and optimize donor heart utilization, ultimately enhancing transplantation success. By identifying recent advancements and proposing future research directions, this review aims to provide insights into advancing heart transplantation and improving patient outcomes.
引用
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页数:15
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