Cataract Surgery in nAMD Patients Receiving Intravitreal Aflibercept Injections

被引:0
作者
Seredyka-Burduk, Malgorzata [1 ]
Liberski, Slawomir [2 ]
Malukiewicz, Grazyna [1 ]
Kociecki, Jaroslaw [2 ]
Kaluzny, Bartlomiej J. [1 ]
机构
[1] Nicolaus Copernicus Univ, Dept Ophthalmol, Div Ophthalmol & Optometry, Coll Med, Kornela Ujejskiego 75 St, PL-85168 Bydgoszcz, Poland
[2] Poznan Univ Med Sci, Dept Ophthalmol, Augustyna Szamarzewskiego 84 St, PL-60569 Poznan, Poland
关键词
cataract; neovascular age-related macular degeneration; anti-VEGF agents; phacoemulsification; ENDOTHELIAL GROWTH-FACTOR; QUALITY-OF-LIFE; MACULAR DEGENERATION; VISUAL-ACUITY; OUTCOMES; THICKNESS; PHACOEMULSIFICATION; POPULATION; DISEASE; EYES;
D O I
10.3390/jcm13133832
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: To evaluate functional and anatomical outcomesof cataract surgery in neovascular age-related macular neovascularization (nAMD) eyes receiving anti-vascular endothelial growth factor (anti-VEGF) intravitreal injections in modified pro re nata (PRN) regimen. Materials and Methods: Sixty eyes of 60 nAMD patients, including 41 women (68.3%) and 19 men (31.7%) in an average age of 77.35 +/- 6.41 years, under treatment with intravitreal aflibercept injections in modified PRN regimen with no signs of macular neovascularization (MNV) activity during two consecutive visits were included in this prospective, observational study. Best-corrected visual acuity (BCVA), central retinal thickness (CRT), as well as the number of anti-VEGF injections were monitored six months before and after phacoemulsification with intraocular lens (IOL) implantation. Further, the change of the abovementioned parameters was assessed during the six-month follow-up period for CRT and the number of injections, while the BCVA was monitored for 54 months. Results: BCVA measured on the first day after surgery (0.17 +/- 0.19 logMAR) as well as in the six-month post-surgery (0.13 +/- 0.16 logMAR) significantly improved compared to preop values (0.42 +/- 0.20 logMAR). BCVA remains stable during the observational period. We found that both differences were statistically significant (p < 0.01). The mean CRT and the mean number of injections did not differ between the six-month pre- and post-surgical periods. Conclusions: We showed the beneficial effect of phacoemulsification in nAMD patients treated with anti-VEGF agents on visual outcomes in the short and long term. Cataract surgery in nAMD eyes treated with anti-VEGF injections does not increase the frequency of anti-VEGF injections and does not cause deterioration of the macular status.
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页数:15
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