Structure and antitumor activity of a polysaccharide from Rosa roxburghii

被引：10
作者：
Liu, Wenhui [1 ]
Li, Na [1 ]
Hou, Jiantong [1 ]
Cao, Ruyu [1 ]
Jia, Lingyun [2 ]
Guo, Yuanqiang [1 ]
Xu, Jing [1 ]
机构：
[1] Nankai Univ, Coll Pharm, State Key Lab Med Chem Biol, Tianjin Key Lab Mol Drug Res, Tianjin 300350, Peoples R China
[2] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang 110016, Peoples R China
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2024年 / 273卷
基金：
中国国家自然科学基金;
关键词：
Rosa roxburghii; Polysaccharide; Antitumor; Immunity; ROS; NO; TRATT FRUIT; IN-VITRO; PROLIFERATION; ANGIOGENESIS; ANTIOXIDANT; CELLS;
D O I：
10.1016/j.ijbiomac.2024.132807
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
It is well known that Rosa roxburghii, as a homology of both medicine and food, is rich in polysaccharides. To discover bioactive macromolecules for combating cancer, the polysaccharides in R. roxburghii were investigated, leading to the purification of a polysaccharide (RRTP80-1). RRTP80-1 was measured to have an average molecular weight of 8.65 x 103 g/mol. Monosaccharide composition analysis revealed that RRTP80-1 was formed from three types of monosaccharides including arabinose, glucose, and galactose. Methylation and GC-MS analysis suggested that the backbone of RRTP80-1 consisted of -*5)-alpha-L-Araf-(1-*, -*6)-alpha-D-Glcp-(1-*, -*2,5)-alpha-LAraf-(1-*, -*4,6)-beta-D-Galp-(1-*, and -*3)-alpha-L-Araf-(1-*, with branch chains composed of alpha-L-Araf-(1-*. In vivo studies indicated that RRTP80-1 exhibited inhibitory activity against the growth and proliferation of neoplasms in the zebrafish tumor xenograft model by suppressing angiogenesis. Additionally, RRTP80-1 was found to upregulate reactive oxygen species (ROS) and nitric oxide (NO) production levels in zebrafish models. All these studies suggest that RRTP80-1 activates the immune system to inhibit tumors. The potential role of the newly discovered homogeneous polysaccharide RRTP80-1 in cancer treatment was preliminarily clarified in this study.
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页数：11
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