Structure and antitumor activity of a polysaccharide from Rosa roxburghii

被引：10

作者：

Liu, Wenhui ^{[1
]}

Li, Na ^{[1
]}

Hou, Jiantong ^{[1
]}

Cao, Ruyu ^{[1
]}

Jia, Lingyun ^{[2
]}

Guo, Yuanqiang ^{[1
]}

Xu, Jing ^{[1
]}

机构：

[1] Nankai Univ, Coll Pharm, State Key Lab Med Chem Biol, Tianjin Key Lab Mol Drug Res, Tianjin 300350, Peoples R China

[2] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang 110016, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2024年 / 273卷

基金：

中国国家自然科学基金;

关键词：

Rosa roxburghii; Polysaccharide; Antitumor; Immunity; ROS; NO; TRATT FRUIT; IN-VITRO; PROLIFERATION; ANGIOGENESIS; ANTIOXIDANT; CELLS;

D O I：

10.1016/j.ijbiomac.2024.132807

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It is well known that Rosa roxburghii, as a homology of both medicine and food, is rich in polysaccharides. To discover bioactive macromolecules for combating cancer, the polysaccharides in R. roxburghii were investigated, leading to the purification of a polysaccharide (RRTP80-1). RRTP80-1 was measured to have an average molecular weight of 8.65 x 103 g/mol. Monosaccharide composition analysis revealed that RRTP80-1 was formed from three types of monosaccharides including arabinose, glucose, and galactose. Methylation and GC-MS analysis suggested that the backbone of RRTP80-1 consisted of -*5)-alpha-L-Araf-(1-*, -*6)-alpha-D-Glcp-(1-*, -*2,5)-alpha-LAraf-(1-*, -*4,6)-beta-D-Galp-(1-*, and -*3)-alpha-L-Araf-(1-*, with branch chains composed of alpha-L-Araf-(1-*. In vivo studies indicated that RRTP80-1 exhibited inhibitory activity against the growth and proliferation of neoplasms in the zebrafish tumor xenograft model by suppressing angiogenesis. Additionally, RRTP80-1 was found to upregulate reactive oxygen species (ROS) and nitric oxide (NO) production levels in zebrafish models. All these studies suggest that RRTP80-1 activates the immune system to inhibit tumors. The potential role of the newly discovered homogeneous polysaccharide RRTP80-1 in cancer treatment was preliminarily clarified in this study.

引用

页数：11

共 63 条

[1] Antineoplastic effect of pectic polysaccharides from green sweet pepper (Capsicum annuum) on mammary tumor cells in vivo and in vitro [J].

Adami, Eliana Rezende ;

Corso, Claudia Rita ;

Turin-Oliveira, Natalia Mulinari ;

Galindo, Claudia Martins ;

Milani, Leticia ;

Stipp, Maria Caroline ;

do Nascimento, Georgia Erdmann ;

Chequin, Andressa ;

da Silva, Luisa Mota ;

de Andrade, Sergio Faloni ;

Dittrich, Rosangela Locatelli ;

Queiroz-Telles, Jose Ederaldo ;

Klassen, Giseli ;

Ramos, Edneia A. S. ;

Cordeiro, Lucimara M. C. ;

Acco, Alexandra .

CARBOHYDRATE POLYMERS, 2018, 201 :280-292

[2] Structure and antiviral activity of sulfated fucans from Stoechospermum marginatum [J].

Adhikari, Utpal ;

Mateii, Cecilia G. ;

Chattopadhyay, Kausik ;

Pujol, Carlos A. ;

Damonte, Elsa B. ;

Ray, Bimalendu .

PHYTOCHEMISTRY, 2006, 67 (22) :2474-2482

[3] Levan from a new isolated Bacillus subtilis AF17: Purification, structural analysis and antioxidant activities [J].

Bouallegue, Amir ;

Casillo, Angela ;

Chaari, Fatma ;

La Gatta, Annalisa ;

Lanzetta, Rosa ;

Corsaro, Maria Michela ;

Bachoual, Rafik ;

Ellouz-Chaabouni, Semia .

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2020, 144 :316-324

[4] Innate Immune System Cells in Atherosclerosis [J].

Chavez-Sanchez, Luis ;

Espinosa-Luna, Jose E. ;

Chavez-Rueda, Karina ;

Legorreta-Haquet, Maria V. ;

Montoya-Diaz, Eduardo ;

Blanco-Favela, Francisco .

ARCHIVES OF MEDICAL RESEARCH, 2014, 45 (01) :1-14

[5] Polyphenol from Rosa roxburghii Tratt Fruit Ameliorates the Symptoms of Diabetes by Activating the P13K/AKT Insulin Pathway in db/db Mice [J].

Chen, Chao ;

Tan, Shuming ;

Ren, Tingyuan ;

Wang, Hua ;

Dai, Xiaotong ;

Wang, Hui .

FOODS, 2022, 11 (05)

[6] Characterization of a novel polysaccharide isolated from Rosa roxburghii Tratt fruit and assessment of its antioxidant in vitro and in vivo [J].

Chen, Guangjing ;

Kan, Jianquan .

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2018, 107 :166-174

[7] Sargassum fusiforme polysaccharides inhibit VEGF-A-related angiogenesis and proliferation of lung cancer in vitro and in vivo [J].

Chen, Huiling ;

Zhang, Ling ;

Long, Xiange ;

Li, Peifei ;

Chen, Shengcan ;

Kuang, Wei ;

Guo, Junming .

BIOMEDICINE & PHARMACOTHERAPY, 2017, 85 :22-27

[8] Polysaccharides from Traditional Chinese Medicines: Extraction, Purification, Modification, and Biological Activity [J].

Chen, Yun ;

Yao, Fangke ;

Ming, Ke ;

Wang, Deyun ;

Hu, Yuanliang ;

Liu, Jiaguo .

MOLECULES, 2016, 21 (12)

[9] Falnidamol and cisplatin combinational treatment inhibits non-small cell lung cancer (NSCLC) by targeting DUSP26-mediated signal pathways [J].

Cui, Zihan ;

Li, Dapeng ;

Zhao, Jun ;

Chen, Kai .

FREE RADICAL BIOLOGY AND MEDICINE, 2022, 183 :106-124

[10] Capsular polysaccharide from a fish-gut bacterium induces/promotes apoptosis of colon cancer cells in vitro through Caspases' pathway activation [J].

Di Guida, Rossella ;

Casillo, Angela ;

Stellavato, Antonietta ;

Kawai, Soichiro ;

Ogawa, Takuya ;

Di Meo, Celeste ;

Kawamoto, Jun ;

Kurihara, Tatsuo ;

Schiraldi, Chiara ;

Corsaro, Maria Michela .

CARBOHYDRATE POLYMERS, 2022, 278

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