Sensory Dysfunction, Microbial Infections, and Host Responses in Alzheimer's Disease

被引：3

作者：

Bathini, Praveen ^{[1
,2
]}

Brai, Emanuele ^{[3
]}

Balin, Brian J. ^{[2
,4
,5
]}

Bimler, Lynn ^{[6
]}

Corry, David B. ^{[2
,6
,7
,8
,9
]}

Devanand, Davangere P. ^{[2
,10
]}

Doty, Richard L. ^{[2
,11
]}

Ehrlich, Garth D. ^{[2
,12
]}

Eimer, William A. ^{[2
,13
,14
,15
,16
]}

Fulop, Tamas ^{[2
,17
]}

Hahn, David L. ^{[2
,5
]}

Hammond, Christine J. ^{[2
,18
]}

Infanti, Joseph ^{[2
,18
]}

Itzhaki, Ruth ^{[2
,19
]}

Lathe, Richard ^{[2
,20
]}

Little, Christopher Scott ^{[2
,4
]}

McLeod, Rima ^{[21
,22
,23
]}

Moein, Shima T. ^{[2
,11
]}

Nelson, Amy R. ^{[24
]}

Perry, George ^{[2
,5
,25
]}

Shemesh, Or A. ^{[2
,5
,26
,27
]}

Tanzi, Rudolph E. ^{[2
,13
,14
,15
,16
]}

Webley, Wilmore C. ^{[2
,5
,28
]}

Schultek, Nikki M. ^{[2
,5
]}

Alberi Auber, Lavinia ^{[2
,3
,5
,29
,30
,31
]}

机构：

[1] Harvard Med Sch, Brigham & Womens Hosp, 60 Fenwood Rd,BTM Hale Bldg, Boston, MA 02115 USA

[2] Alzheimers Pathobiome Initiat AlzPI, Wake Forest, NC 27157 USA

[3] BrainFit4Life, Fribourg, Switzerland

[4] Philadelphia Coll Osteopath Med, Ctr Chron Disorders Aging, Philadelphia, PA USA

[5] Intracell Res Grp LLC, Wake Forest, NC USA

[6] Baylor Coll Med, Dept Med, Houston, TX USA

[7] Baylor Coll Med, Dan L Duncan Comprehens Canc Ctr, Biol Inflammat Ctr, Dept Med, Houston, TX USA

[8] Baylor Coll Med, Michael E DeBakey VA Ctr Translat Res Inflammatory, Houston, TX USA

[9] Dan L Duncan Comprehens Canc Ctr, Biol Inflammat Ctr, Dept Pathol & Immunol, Houston, TX USA

[10] Columbia Univ, Irving Med Ctr, Dept Psychiat & Neurol, New York, NY USA

[11] Univ Penn, Smell & Taste Ctr, Perelman Sch Med, Dept Otorhinolaryngol Head & Neck Surg, Philadelphia, PA USA

[12] Drexel Univ, Coll Med, Inst Mol Med & Infect Dis, Ctr Genom Sci,Dept Microbiol & Immunol, Philadelphia, PA USA

[13] Mass Gen Inst Neurodegenerat Dis, Genet & Aging Res Unit, Charlestown, MA USA

[14] Massachusetts Gen Hosp, Dept Neurol, Charlestown, MA USA

[15] Harvard Med Sch, Charlestown, MA USA

[16] Harvard Univ, Harvard Med Sch, Cambridge, MA USA

[17] Univ Sherbrooke, Fac Med & Hlth Sci, Dept Med, Res Ctr Aging,Div Geriatr, Sherbrooke, PQ, Canada

[18] Philadelphia Coll Osteopath Med, Div Res, Philadelphia, PA USA

[19] Univ Oxford, Inst Populat Ageing, Oxford, England

[20] Univ Edinburgh, Div Infect Med, Med Sch, Edinburgh, Scotland

[21] Univ Chicago, Dept Ophthalmol, Chicago, IL USA

[22] Univ Chicago, Dept Visual Sci, Chicago, IL USA

[23] Univ Chicago, Dept Pediat Infect Dis, Chicago, IL USA

[24] Univ S Alabama, Dept Physiol & Cell Biol, Mobile, AL USA

[25] Univ Texas San Antonio, Dept Biol, San Antonio, TX USA

[26] Univ Pittsburgh, Sch Med, Dept Neurobiol, Pittsburgh, PA USA

[27] Univ Pittsburgh, Sch Med, Dept Bioengn, Pittsburgh, PA USA

[28] Univ Massachusetts, Dept Microbiol, Amherst, MA USA

[29] Univ Fribourg, Dept Med, Fribourg, Switzerland

[30] VitalizeDx, Epalinges, Switzerland

[31] VitalizeDx Eu, Trieste, Italy

来源：

JOURNAL OF INFECTIOUS DISEASES | 2024年 / 230卷

基金：

美国国家卫生研究院;

关键词：

sensory dysfunction; host-pathogen interaction; Alzheimer's disease; microbes; parasites; SIMPLEX-VIRUS TYPE-1; CHLAMYDIA-PNEUMONIAE INFECTION; NEURODEGENERATIVE DISEASES; FUNGAL-INFECTION; NERVOUS-SYSTEM; AMYLOID-BETA; DEMENTIA; BRAIN; HEARING; ASSOCIATION;

D O I：

10.1093/infdis/jiae328

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Sensory functions of organs of the head and neck allow humans to interact with the environment and establish social bonds. With aging, smell, taste, vision, and hearing decline. Evidence suggests that accelerated impairment in sensory abilities can reflect a shift from healthy to pathological aging, including the development of Alzheimer's disease (AD) and other neurological disorders. While the drivers of early sensory alteration in AD are not elucidated, insults such as trauma and infections can affect sensory function. Herein, we review the involvement of the major head and neck sensory systems in AD, with emphasis on microbes exploiting sensory pathways to enter the brain (the "gateway" hypothesis) and the potential feedback loop by which sensory function may be impacted by central nervous system infection. We emphasize detection of sensory changes as first-line surveillance in senior adults to identify and remove potential insults, like microbial infections, that could precipitate brain pathology.

引用

页码：S150 / S164

页数：15

共 154 条

[41] STRING v9.1: protein-protein interaction networks, with increased coverage and integration [J].

Franceschini, Andrea ;

Szklarczyk, Damian ;

Frankild, Sune ;

Kuhn, Michael ;

Simonovic, Milan ;

Roth, Alexander ;

Lin, Jianyi ;

Minguez, Pablo ;

Bork, Peer ;

von Mering, Christian ;

Jensen, Lars J. .

NUCLEIC ACIDS RESEARCH, 2013, 41 (D1) :D808-D815

[42] Olfactory epithelium changes in germfree mice [J].

Francois, Adrien ;

Grebert, Denise ;

Rhimi, Moez ;

Mariadassou, Mahendra ;

Naudon, Laurent ;

Rabot, Sylvie ;

Meunier, Nicolas .

SCIENTIFIC REPORTS, 2016, 6

[43] Role of Microbes in the Development of Alzheimer's Disease: State of the Art - An International Symposium Presented at the 2017 IAGG Congress in San Francisco [J].

Fulop, Tamas ;

Itzhaki, Ruth F. ;

Balin, Brian J. ;

Miklossy, Judith ;

Barron, Annelise E. .

FRONTIERS IN GENETICS, 2018, 9

[44] HEARING IN THE ELDERLY - THE FRAMINGHAM COHORT, 1983-1985 .1. BASIC AUDIOMETRIC TEST-RESULTS [J].

GATES, GA ;

COOPER, JC ;

KANNEL, WB ;

MILLER, NJ .

EAR AND HEARING, 1990, 11 (04) :247-256

[45] The load of Chlamydia pneumoniae in the Alzheimer's brain varies with APOE genotype [J].

Gérard, HC ;

Wildt, KL ;

Whittum-Hudson, JA ;

Lai, ZS ;

Ager, J ;

Hudson, AP .

MICROBIAL PATHOGENESIS, 2005, 39 (1-2) :19-26

[46] Chlamydophila (Chlamydia) pneumoniae in the Alzheimer's brain [J].

Gerard, Herve C. ;

Dreses-Werringloer, Ute ;

Wildt, Kristin S. ;

Deka, Srilekha ;

Oszust, Cynthia ;

Balin, Brian J. ;

Frey, William H., II ;

Bordayo, Elizabeth Z. ;

Whittum-Hudson, Judith A. ;

Hudson, Alan P. .

FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, 2006, 48 (03) :355-366

[47] Cytosolic β-amyloid deposition and supranuclear cataracts in lenses from people with Alzheimer's disease [J].

Goldstein, LE ;

Muffat, JA ;

Cherny, RA ;

Moir, RD ;

Ericsson, MH ;

Huang, XD ;

Mavros, C ;

Coccia, JA ;

Faget, KY ;

Fitch, KA ;

Masters, CL ;

Tanzi, RE ;

Chylack, LT ;

Bush, AI .

LANCET, 2003, 361 (9365) :1258-1265

[48] Observed Hearing Loss and Incident Dementia in a Multiethnic Cohort [J].

Golub, Justin S. ;

Luchsinger, Jose A. ;

Manly, Jennifer J. ;

Stern, Yaakov ;

Mayeux, Richard ;

Schupf, Nicole .

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2017, 65 (08) :1691-1697

[49] Olfactory dysfunction and its related molecular mechanisms in Parkinson's disease [J].

Gu, Yingying ;

Zhang, Jiaying ;

Zhao, Xinru ;

Nie, Wenyuan ;

Xu, Xiaole ;

Liu, Mingxuan ;

Zhang, Xiaoling .

NEURAL REGENERATION RESEARCH, 2024, 19 (03) :583-590

[50] Activation of latent Lyme borreliosis concurrent with a herpes simplex virus type 1 infection [J].

Gylfe, Å ;

Wahlgren, M ;

Fahlén, L ;

Bergström, S .

SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES, 2002, 34 (12) :922-924

← 1 2 3 4 5 6 7 8 9 10 →