Mechanism of antibacterial resistance, strategies and next-generation antimicrobials to contain antimicrobial resistance: a review

被引：31

作者：

Belay, Wubetu Yihunie ^{[1
]}

Getachew, Melese ^{[1
]}

Tegegne, Bantayehu Addis ^{[1
]}

Teffera, Zigale Hibstu ^{[2
]}

Dagne, Abebe ^{[1
]}

Zeleke, Tirsit Ketsela ^{[1
]}

Abebe, Rahel Belete ^{[3
]}

Gedif, Abebaw Abie ^{[1
]}

Fenta, Abebe ^{[2
]}

Yirdaw, Getasew ^{[4
]}

Tilahun, Adane ^{[2
]}

Aschale, Yibeltal ^{[2
]}

机构：

[1] Debre Markos Univ, Coll Hlth Sci, Dept Pharm, Debre Markos, Ethiopia

[2] Debre Markos Univ, Coll Hlth Sci, Dept Med Lab Sci, Debre Markos, Ethiopia

[3] Univ Gondar, Coll Med & Hlth Sci, Dept Clin Pharm, Gondar, Ethiopia

[4] Debre Markos Univ, Coll Hlth Sci, Dept Environm Hlth Sci, Debre Markos, Ethiopia

来源：

FRONTIERS IN PHARMACOLOGY | 2024年 / 15卷

关键词：

modification of target; decreased accumulation; enzymatic inactivation; biofilm formation; horizontal gene transfer; next-generation antimicrobials; GRAM-NEGATIVE BACTERIA; NATURAL GENETIC-TRANSFORMATION; SALMONELLA GENOMIC ISLAND-1; ANTIBIOTIC-RESISTANCE; EFFLUX PUMPS; PSEUDOMONAS-AERUGINOSA; ACINETOBACTER-BAUMANNII; MULTIDRUG-RESISTANCE; STAPHYLOCOCCUS-AUREUS; MOLECULAR-MECHANISMS;

D O I：

10.3389/fphar.2024.1444781

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Antibacterial drug resistance poses a significant challenge to modern healthcare systems, threatening our ability to effectively treat bacterial infections. This review aims to provide a comprehensive overview of the types and mechanisms of antibacterial drug resistance. To achieve this aim, a thorough literature search was conducted to identify key studies and reviews on antibacterial resistance mechanisms, strategies and next-generation antimicrobials to contain antimicrobial resistance. In this review, types of resistance and major mechanisms of antibacterial resistance with examples including target site modifications, decreased influx, increased efflux pumps, and enzymatic inactivation of antibacterials has been discussed. Moreover, biofilm formation, and horizontal gene transfer methods has also been included. Furthermore, measures (interventions) taken to control antimicrobial resistance and next-generation antimicrobials have been discussed in detail. Overall, this review provides valuable insights into the diverse mechanisms employed by bacteria to resist the effects of antibacterial drugs, with the aim of informing future research and guiding antimicrobial stewardship efforts.

引用

页数：26

共 321 条

[1]

Aarestrup Frank M., 2006, pXI

[2] Acinetobacter baumannii Efflux Pumps and Antibiotic Resistance [J].

Abdi, Seyyed Naser ;

Ghotaslou, Reza ;

Ganbarov, Khudaverdi ;

Mobed, Ahmad ;

Tanomand, Asghar ;

Yousefi, Mehdi ;

Asgharzadeh, Mohammad ;

Kafil, Hossein Samadi .

INFECTION AND DRUG RESISTANCE, 2020, 13 :423-434

[3] One Health: A new definition for a sustainable and healthy future [J].

Adisasmito, Wiku B. ;

Almuhairi, Salama ;

Behravesh, Casey Barton ;

Bilivogui, Pepe ;

Bukachi, Salome A. ;

Casas, Natalia ;

Becerra, Natalia Cediel ;

Charron, Dominique F. ;

Chaudhary, Abhishek ;

Zanella, Janice R. Ciacci ;

Cunningham, Andrew A. ;

Dar, Osman ;

Debnath, Nitish ;

Dungu, Baptiste ;

Farag, Elmoubasher ;

Gao, George F. ;

Hayman, David T. S. ;

Khaitsa, Margaret ;

Koopmans, Marion P. G. ;

Machalaba, Catherine ;

Mackenzie, John S. ;

Markotter, Wanda ;

Mettenleiter, Thomas C. ;

Morand, Serge ;

Smolenskiy, Vyacheslav ;

Zhou, Lei .

PLOS PATHOGENS, 2022, 18 (06)

[4] Role of Aminoglycoside-Modifying Enzymes (AMEs) in Resistance to Aminoglycosides among Clinical Isolates of Pseudomonas aeruginosa in the North of Iran [J].

Ahmadian, Leila ;

Bazgir, Zahra Norouzi ;

Ahanjan, Mohammad ;

Valadan, Reza ;

Goli, Hamid Reza .

BIOMED RESEARCH INTERNATIONAL, 2021, 2021

[5] Synergistic Action of Phage and Antibiotics: Parameters to Enhance the Killing Efficacy Against Mono and Dual-Species Biofilms [J].

Akturk, Ergun ;

Oliveira, Hugo ;

Santos, Silvio B. ;

Costa, Susana ;

Kuyumcu, Suleyman ;

Melo, Luis D. R. ;

Azeredo, Joana .

ANTIBIOTICS-BASEL, 2019, 8 (03)

[6] Mechanism of Quinolone Action and Resistance [J].

Aldred, Katie J. ;

Kerns, Robert J. ;

Osheroff, Neil .

BIOCHEMISTRY, 2014, 53 (10) :1565-1574

[7] Drug Efflux Pump Inhibitors: A Promising Approach to Counter Multidrug Resistance in Gram-Negative Pathogens by Targeting AcrB Protein from AcrAB-TolC Multidrug Efflux Pump from Escherichia coli [J].

Alenazy, Rawaf .

BIOLOGY-BASEL, 2022, 11 (09)

[8] Artificial Intelligence for Antimicrobial Resistance Prediction: Challenges and Opportunities towards Practical Implementation [J].

Ali, Tabish ;

Ahmed, Sarfaraz ;

Aslam, Muhammad .

ANTIBIOTICS-BASEL, 2023, 12 (03)

[9]

Aly HAA, 2015, WHO TECH REP SER, V994, P1

[10] The role of metabolism in bacterial persistence [J].

Amato, Stephanie M. ;

Fazen, Christopher H. ;

Henry, Theresa C. ;

Mok, Wendy W. K. ;

Orman, Mehmet A. ;

Sandvik, Elizabeth L. ;

Volzing, Katherine G. ;

Brynildsen, Mark P. .

FRONTIERS IN MICROBIOLOGY, 2014, 5

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