Diabetes cardiomyopathy: targeted regulation of mitochondrial dysfunction and therapeutic potential of plant secondary metabolites

被引:5
作者
Pan, Xianglong [1 ]
Hao, Erwei [2 ,3 ,4 ]
Zhang, Fan [2 ,3 ,4 ]
Wei, Wei [2 ,3 ,4 ]
Du, Zhengcai [2 ,3 ,4 ]
Yan, Guangli [1 ]
Wang, Xijun [1 ]
Deng, Jiagang [2 ,3 ,4 ]
Hou, Xiaotao [1 ,2 ,3 ,4 ]
机构
[1] Heilongjiang Univ Chinese Med, Dept Pharmaceut, Harbin, Heilongjiang, Peoples R China
[2] Guangxi Univ Chinese Med, Guangxi Key Lab Efficacy Study Chinese Mat Med, Nanning, Guangxi, Peoples R China
[3] Guangxi Univ Chinese Med, Guangxi Collaborat Innovat Ctr Res Funct Ingredien, Nanning, Guangxi, Peoples R China
[4] Guangxi Univ Chinese Med, Guangxi Key Lab TCM Formulas Theory & Transformat, Nanning, Guangxi, Peoples R China
基金
中国国家自然科学基金;
关键词
diabetic cardiomyopathy; mitochondrial dynamics; oxidative stress; mitophagy; insulin resistance; plant secondary metabolites; ISCHEMIA-REPERFUSION INJURY; IMPROVES CARDIAC-FUNCTION; OXIDATIVE STRESS; INSULIN-RESISTANCE; ENERGY-METABOLISM; HEART-FAILURE; ASTRAGALUS POLYSACCHARIDES; MYOCARDIAL APOPTOSIS; MOLECULAR-MECHANISMS; UNCOUPLING PROTEINS;
D O I
10.3389/fphar.2024.1401961
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Diabetic cardiomyopathy (DCM) is a specific heart condition in diabetic patients, which is a major cause of heart failure and significantly affects quality of life. DCM is manifested as abnormal cardiac structure and function in the absence of ischaemic or hypertensive heart disease in individuals with diabetes. Although the development of DCM involves multiple pathological mechanisms, mitochondrial dysfunction is considered to play a crucial role. The regulatory mechanisms of mitochondrial dysfunction mainly include mitochondrial dynamics, oxidative stress, calcium handling, uncoupling, biogenesis, mitophagy, and insulin signaling. Targeting mitochondrial function in the treatment of DCM has attracted increasing attention. Studies have shown that plant secondary metabolites contribute to improving mitochondrial function and alleviating the development of DCM. This review outlines the role of mitochondrial dysfunction in the pathogenesis of DCM and discusses the regulatory mechanism for mitochondrial dysfunction. In addition, it also summarizes treatment strategies based on plant secondary metabolites. These strategies targeting the treatment of mitochondrial dysfunction may help prevent and treat DCM.
引用
收藏
页数:23
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